Company lists · Data refreshed September 2026
Top 25 Enzyme replacement therapy companies based in the United States
RevenueBase identified 133 enzyme replacement therapy companies headquartered in the United States as of September 2026 and tracks 1,731 professional contacts across them, including 639 with verified work emails. Boca Raton is the largest hub.
This list covers enzyme replacement therapy companies headquartered in the United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, its RevenueBase Smart Search rating, and when it was last checked. Data refreshed September 19, 2026.
Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase Smart Search, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.
The 25 largest enzyme replacement therapy companies based in the United States
Ranked by team size| # | Company | Contacts | |||
|---|---|---|---|---|---|
| 1 | 389 contacts → | ||||
Indirect evidence “New U Life® is THE hormone health company!” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 2 | 326 contacts → | ||||
Indirect evidence “Sobi is an international specialty healthcare company dedicated to developing treatments and extensive patient support networks for people with rare and difficult to treat…” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 3 | 162 contacts → | ||||
Indirect evidence “As a central aspect of men’s and women’s health, hormones play a key role in balanced emotions, energy, metabolism, and more especially as we age.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 4 | 83 contacts → | ||||
Strong evidence “Alcresta Therapeutics is dedicated to developing and commercializing novel, enzyme-based products designed to address challenges faced by people living with gastrointestinal…” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 5 | 74 contacts → | ||||
Indirect evidence “Doctor prescribed treatments for menopause symptoms.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 6 | 48 contacts → | ||||
Partial evidence “We are a biopharmaceutical company specializing in the development of novel therapeutics to treat rare metabolic diseases.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 7 | 34 contacts → | ||||
Indirect evidence “Most people are told their labs are normal while they're still exhausted, foggy, and feeling like a stranger in their own body.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 8 | 26 contacts → | ||||
Partial evidence “Anagram is a clinical stage company leveraging proprietary enzyme technologies and expertise in gastrointestinal diseases to solve complex problems and advance a pipeline of…” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 9 | 25 contacts → | ||||
Strong evidence “Renew Vitality is a nationwide leader in hormone replacement therapy, peptide therapy, weight loss programs, sexual health, and performance supplements.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 10 | 25 contacts → | ||||
Indirect evidence “We help men boost their testosterone up to a healthy, normal level using testosterone cream.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 11 | 24 contacts → | ||||
Partial evidence “Glycomine is developing orphan drugs for serious rare disorders of metabolism and protein misfolding for which no other therapeutic options exist.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 12 | 18 contacts → | ||||
Strong evidence “M6P Therapeutics is developing the next-generation enzyme replacement and gene therapies for lysosomal storage disorders.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 13 | 16 contacts → | ||||
Strong evidence “Purepell is a premier provider of turnkey Bioidentical Hormone Replacement Therapy (BHRT) solutions for medical practices.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 14 | 15 contacts → | ||||
Indirect evidence “At Hormone Logics we have one combined goal, to get you looking your best and feeling in your 20s again using bio identical hormones.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 15 | 15 contacts → | ||||
Strong evidence “Hormone Replacement Therapy for both Men and Women through the ease of TeleMedicine.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 16 | 14 contacts → | ||||
Partial evidence “JangoBio is developing regenerative therapies to reverse hormone imbalances associated with aging and thereby mitigate the risk of developing a wide range of age-related diseases.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 17 | 11 contacts → | ||||
Indirect evidence “At LifeXMD we take pride in providing you with personalized, high quality services designed to help you achieve your unique health and fitness goals.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 18 | 11 contacts → | ||||
Strong evidence “Full Potential HRT Clinic provides Portland, Oregon and Seattle, Washington with unrivaled state-of-the-art testosterone replacement therapy (TRT), human growth hormone (HGH)…” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 19 | 11 contacts → | ||||
Strong evidence “viTal4men specializes in testosterone replacement therapy for men!” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 20 | 11 contacts → | ||||
Indirect evidence “Pellecome LLC is a company of scientists and clinicians that was established to provide physicians with a safer, faster and more reliable delivery system for bio-Identical hormone…” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 21 | 10 contacts → | ||||
Partial evidence “BioPro+ is the #1 Non-Synthetic Alternative to Rx HGH and Peptide Therapies.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 22 | 10 contacts → | ||||
Partial evidence “Elevate your practice with Bella Vita's BHRT - Pellet Therapy and industry-leading training.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 23 | 10 contacts → | ||||
Indirect evidence Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 24 | 10 contacts → | ||||
Strong evidence “WePellet is a breakthrough medical company that solely focuses on optimizing patient’s hormones through bioidentical hormone replacement therapy.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
| 25 | 10 contacts → | ||||
Indirect evidence “At HRT Health, we are dedicated to helping both men and women achieve optimal hormone balance and overall well-being through modern medicine.” Source: RevenueBase Database · checked Sep 19, 2026Thanks. The Data Team will review it. | |||||
RevenueBase Smart Search
RevenueBase Smart Search assesses information from a company’s LinkedIn profile, information supplied directly by the company, its website, and other publicly available sources. It uses that information to rate how closely the company relates to this list’s category: enzyme replacement therapy companies. Every row carries its rating and the description the rating was read from, so each one can be checked rather than taken on trust.
- Strong evidence
- The company's own public description of its business names enzyme replacement therapy companies.
- Partial evidence
- Its own public description names part of enzyme replacement therapy companies, so it works in or next to the category without describing itself that way.
- Indirect evidence
- The description shown does not name enzyme replacement therapy companies. The match rests on the rest of the company's public profile rather than the one sentence quoted here, so this is the rating to check first.
RevenueBase Smart Search is how these lists are built: RevenueBase's data engine and AI assemble the companies that match a category defined in a user's own words, so a list can be about what companies actually do rather than about whichever industry code they were filed under.
Showing 25 of 133 enzyme replacement therapy companies based in the United States
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Enzyme replacement therapy companies based in the United States at a glance
As of Sep 19, 2026Companies by employee count
Email recency for this list is measured worldwide rather than for United States, so it is reported there. Company counts and contact totals on this page are exact for United States, over 133 companies.
How this list was built
Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among enzyme replacement therapy companies, so some rows will be adjacent to the category rather than pure plays. The description and RevenueBase Smart Search rating on every row are there so you can check each match yourself.
- Source
- The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase Smart Search, the natural-language company search available to every RevenueBase user.
- What qualifies
- Companies headquartered in the United States whose own description of what they do matches “enzyme replacement therapy companies”. Matching reads each company's description, not its industry code or its name.
- RevenueBase Smart Search
- RevenueBase Smart Search is how this list is assembled and how each row is rated. RevenueBase's data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to a category defined in a user's own words. Each row is rated strong evidence (its own description names enzyme replacement therapy companies), partial evidence (it names part of the category) or indirect evidence (the description shown names none of it and the match rests on the rest of the company's profile). The description supporting each rating is quoted on the row.
- What we exclude
- Companies whose own description does not clearly place them among enzyme replacement therapy companies, and records with no verified work email. Companies headquartered outside United States are excluded even when they keep an office there.
- Match quality
- In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and its RevenueBase Smart Search rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
- Ranking
- Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
- Verification
- Every listed company carries at least one verified work email, 639 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
- Refresh
- This page's figures were pulled from the company graph on September 19, 2026. Lists refresh periodically as the graph is re-checked.
- Corrections
- Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.
Frequently asked
What is RevenueBase Smart Search?
RevenueBase Smart Search is how RevenueBase decides which companies belong on this list and how strongly each one fits. Its data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to the category the list is about. Each row is rated strong evidence when the company's own description names enzyme replacement therapy companies, partial evidence when it names part of the category, and indirect evidence when the description shown names none of it and the match rests on the rest of the company's profile.
How many enzyme replacement therapy companies are there based in the United States?
RevenueBase identified 133 enzyme replacement therapy companies headquartered in the United States as of September 2026, matched on each company's own description of what it does rather than its industry code.
What is the largest company on this list?
NEW U Life, headquartered in Pleasant Hill, tops this list with the largest team on record.
Which city has the most enzyme replacement therapy companies?
Boca Raton leads with 4 headquartered companies, followed by Austin (3) and Boston (3).
How do I get contact information for these companies?
A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 639 verified decision-maker contacts tracked across these 133 companies.
How current is this list?
The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 19, 2026.
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About this data
RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase Smart Search, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.
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