Company lists · Data refreshed September 2026

Top 25 Biotech startups based in the United States

Name: Biotech startups based in the United States
Creator: RevenueBase
License: https://creativecommons.org/licenses/by/4.0/

Compiled by the RevenueBase Data Team Data refreshed Sep 16, 2026 692 companies tracked

RevenueBase identified 692 biotech startups headquartered in the United States as of September 2026 and tracks 9,311 professional contacts across them, including 3,510 with verified work emails. San Francisco is the largest hub.

This list covers biotech startups headquartered in the United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, its RevenueBase Smart Search rating, and when it was last checked. Data refreshed September 16, 2026.

Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase Smart Search, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.

How to read this list HQ checked on every row RevenueBase Smart Search rating on every row Refreshed Sep 16, 2026 86% judged on-target in blind review

692Companies

9,311Contacts tracked

3,510Verified emails

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The 25 largest biotech startups based in the United States

Ranked by team size

Top 25 of 692 biotech startups based in the United States, ranked by team size, largest first. Data refreshed Sep 16, 2026. RevenueBase Smart Search rates how each company's information relates to biotech startups: strong evidence (its own description names it), partial (names part of it), indirect (matched on the rest of its profile rather than the description shown). Click a contact count to view that company's people.
#	Company	RevenueBase Smart Search	Headquarters	Employees	Contacts
1	Aldevron	Indirect evidence	Fargo, ND, United StatesHQ checked Sep 16, 2026	1,001-5,000	802 contacts →
	Indirect evidence “Aldevron is proud to be part of Danaher.” Source: RevenueBase Database · checked Sep 16, 2026
2	Recursion	Indirect evidence	Salt Lake City, UT, United StatesHQ checked Sep 16, 2026	501-1,000	793 contacts →
	Indirect evidence “Recursion (NASDAQ: RXRX) is a clinical stage TechBio company leading the space by decoding biology to radically improve lives.” Source: RevenueBase Database · checked Sep 16, 2026
3	Flagship Pioneering	Partial evidence	Cambridge, MA, United StatesHQ checked Sep 16, 2026	501-1,000	753 contacts →
	Partial evidence “Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple transformative human health and sustainability…” Source: RevenueBase Database · checked Sep 16, 2026
4	Biotechnology Innovation Organization	Partial evidence	Washington, DC, United StatesHQ checked Sep 16, 2026	n/a	695 contacts →
	Partial evidence “BIO is the premier biotechnology advocacy organization representing biotech companies, industry leaders, and state biotech associations in the United States and more than 35…” Source: RevenueBase Database · checked Sep 16, 2026
5	Nucleate	Partial evidence	Boston, United StatesHQ checked Sep 16, 2026	51-200	424 contacts →
	Partial evidence “Nucleate is a free, trainee-led 501(c)(3) non-profit organization dedicated to empowering the next generation of biotech leaders.” Source: RevenueBase Database · checked Sep 16, 2026
6	Alchemist Accelerator	Indirect evidence	San Francisco, CA, United StatesHQ checked Sep 16, 2026	n/a	321 contacts →
	Indirect evidence “The Alchemist Accelerator is a venture-backed initiative focused on accelerating the development of seed-stage ventures that monetize from enterprises (not consumers).” Source: RevenueBase Database · checked Sep 16, 2026
7	Atlas Venture	Partial evidence	Cambridge, MA, United StatesHQ checked Sep 16, 2026	11-50	123 contacts →
	Partial evidence “Atlas Venture is a leading biotech venture capital firm.” Source: RevenueBase Database · checked Sep 16, 2026
8	SOSV	Partial evidence	Princeton, NJ, United StatesHQ checked Sep 16, 2026	51-200	119 contacts →
	Partial evidence “SOSV is the most active deep tech venture capital firm globally, investing at pre-seed (or at startup inception) supporting visionary founders intent on making a profound impact…” Source: RevenueBase Database · checked Sep 16, 2026
9	Biolabs	Partial evidence	Cambridge, MA, United StatesHQ checked Sep 16, 2026	51-200	110 contacts →
	Partial evidence “BioLabs are the premier co-working spaces for life science startups- unique places where you can test, develop and grow your game-changing ideas.” Source: RevenueBase Database · checked Sep 16, 2026
10	Band Of Angels	Indirect evidence	San Francisco, CA, United StatesHQ checked Sep 16, 2026	51-200	97 contacts →
	Indirect evidence “The Band of Angels is Silicon Valley's oldest seed funding organization.” Source: RevenueBase Database · checked Sep 16, 2026
11	MPM Bioimpact	Partial evidence	Boston, MA, United StatesHQ checked Sep 16, 2026	11-50	95 contacts →
	Partial evidence “MPM BioImpact is a world-leading biotechnology investment firm with nearly three decades of experience creating and investing in companies that seek to translate scientific…” Source: RevenueBase Database · checked Sep 16, 2026
12	Bioprocure, LLC	Indirect evidence	Burlington, MA, United StatesHQ checked Sep 16, 2026	51-200	88 contacts →
	Indirect evidence “BioProcure aims to keep researchers in the lab - doing science!” Source: RevenueBase Database · checked Sep 16, 2026
13	Venrock	Indirect evidence	Palo Alto, CA, United StatesHQ checked Sep 16, 2026	51-200	71 contacts →
	Indirect evidence “Originally established as the venture capital arm of the Rockefeller family in 1969, Venrock partners with entrepreneurs to build some of the world’s most disruptive, successful…” Source: RevenueBase Database · checked Sep 16, 2026
14	Portal Innovations	Indirect evidence	Chicago, IL, United StatesHQ checked Sep 16, 2026	11-50	67 contacts →
	Indirect evidence “Portal Innovations is a premier venture development engine that bridges scientific ideation in life sciences, medtech, and bioinformatics through commercial proof of concept by…” Source: RevenueBase Database · checked Sep 16, 2026
15	Proteinea	Partial evidence	Cambridge, MA, United StatesHQ checked Sep 16, 2026	11-50	59 contacts →
	Partial evidence “Proteinea is a pioneering TechBio company transforming drug discovery and development by integrating advanced biotechnology with artificial intelligence.” Source: RevenueBase Database · checked Sep 16, 2026
16	Sosv HAX	Partial evidence	Newark, NJ, United StatesHQ checked Sep 16, 2026	11-50	56 contacts →
	Partial evidence “SOSV is the most active deep tech venture capital firm globally, investing at pre-seed (or at startup inception) supporting visionary founders intent on making a profound impact…” Source: RevenueBase Database · checked Sep 16, 2026
17	Spear BIO	Indirect evidence	Boston, MA, United StatesHQ checked Sep 16, 2026	11-50	55 contacts →
	Indirect evidence “Spear Bio, founded in 2021, is a well-funded and rapidly growing start-up headquartered in Woburn, Massachusetts.” Source: RevenueBase Database · checked Sep 16, 2026
18	TCG Labs Soleil	Partial evidence	South San Francisco, CA, United StatesHQ checked Sep 16, 2026	11-50	54 contacts →
	Partial evidence “At TCG Labs Soleil, we are establishing a pioneering venture-biotech model in collaboration with The Column Group.” Source: RevenueBase Database · checked Sep 16, 2026
19	Drummond Scientific Company	Partial evidence	Broomall, PA, United StatesHQ checked Sep 16, 2026	51-200	53 contacts →
	Partial evidence “Drummond Scientific is a leader in developing custom scalable manufacturing solutions for biotech companies worldwide.” Source: RevenueBase Database · checked Sep 16, 2026
20	OPTIC	Indirect evidence	San Francisco, CA, United StatesHQ checked Sep 16, 2026	11-50	51 contacts →
	Indirect evidence “AI-powered drug discovery platform for rapid molecule screening and testing, from target identification to lab validation.” Source: RevenueBase Database · checked Sep 16, 2026
21	Aditum BIO	Indirect evidence	Oakland, CA, United StatesHQ checked Sep 16, 2026	51-200	50 contacts →
	Indirect evidence “Aditum Bio, from the Latin word for “access”, was founded on a simple mission: to give patients access to medicines that may not otherwise be developed.” Source: RevenueBase Database · checked Sep 16, 2026
22	Innosphere	Partial evidence	Fort Collins, CO, United StatesHQ checked Sep 16, 2026	11-50	49 contacts →
	Partial evidence “Innosphere accelerates the success of high-impact science and technology-based startup and scaleup companies.” Source: RevenueBase Database · checked Sep 16, 2026
23	Orgenesis INC	Partial evidence	Germantown, MD, United StatesHQ checked Sep 16, 2026	51-200	47 contacts →
	Partial evidence “Orgenesis is a global biotech company that has been committed to unlocking the potential of decentralized cell and gene therapies (CGTs) since 2012.” Source: RevenueBase Database · checked Sep 16, 2026
24	Bakar BIO Labs	Indirect evidence	Berkeley, CA, United StatesHQ checked Sep 16, 2026	n/a	44 contacts →
	Indirect evidence “Bakar Labs is the flagship life science-focused incubator at UC Berkeley’s Bakar BioEnginuity Hub.” Source: RevenueBase Database · checked Sep 16, 2026
25	MBC Biolabs	Partial evidence	San Francisco, CA, United StatesHQ checked Sep 16, 2026	11-50	44 contacts →
	Partial evidence “MBC BioLabs believes startups are the greatest force for positive change in the world.” Source: RevenueBase Database · checked Sep 16, 2026

RevenueBase Smart Search

RevenueBase Smart Search assesses information from a company’s LinkedIn profile, information supplied directly by the company, its website, and other publicly available sources. It uses that information to rate how closely the company relates to this list’s category: biotech startups. Every row carries its rating and the description the rating was read from, so each one can be checked rather than taken on trust.

Strong evidence: The company's own public description of its business names biotech startups.
Partial evidence: Its own public description names part of biotech startups, so it works in or next to the category without describing itself that way.
Indirect evidence: The description shown does not name biotech startups. The match rests on the rest of the company's public profile rather than the one sentence quoted here, so this is the rating to check first.

RevenueBase Smart Search is how these lists are built: RevenueBase's data engine and AI assemble the companies that match a category defined in a user's own words, so a list can be about what companies actually do rather than about whichever industry code they were filed under.

Showing 25 of 692 biotech startups based in the United States

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Biotech startups based in the United States at a glance

As of Sep 16, 2026

37.7%Verified-email coverage

13.5Average contacts per company

1-10Median size (employees)

6.6%Largest-city concentration · San Francisco

Sep 16, 2026Page data refreshed

Companies by employee count

1-10

464

11-50

179

51-200

201-500

501-1,000

1,001-5,000

10001+

Email recency for this list is measured worldwide rather than for United States, so it is reported there. Company counts and contact totals on this page are exact for United States, over 692 companies.

How this list was built

Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among biotech startups, so some rows will be adjacent to the category rather than pure plays. The description and RevenueBase Smart Search rating on every row are there so you can check each match yourself.

Source: The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase Smart Search, the natural-language company search available to every RevenueBase user.
What qualifies: Companies headquartered in the United States whose own description of what they do matches “biotech startups”. Matching reads each company's description, not its industry code or its name.
RevenueBase Smart Search: RevenueBase Smart Search is how this list is assembled and how each row is rated. RevenueBase's data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to a category defined in a user's own words. Each row is rated strong evidence (its own description names biotech startups), partial evidence (it names part of the category) or indirect evidence (the description shown names none of it and the match rests on the rest of the company's profile). The description supporting each rating is quoted on the row.
What we exclude: Companies whose own description does not clearly place them among biotech startups, and records with no verified work email. Companies headquartered outside United States are excluded even when they keep an office there.
Match quality: In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and its RevenueBase Smart Search rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
Ranking: Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
Verification: Every listed company carries at least one verified work email, 3,510 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
Refresh: This page's figures were pulled from the company graph on September 16, 2026. Lists refresh periodically as the graph is re-checked.
Corrections: Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.

Biotech startups by metro

Frequently asked

What is RevenueBase Smart Search?

RevenueBase Smart Search is how RevenueBase decides which companies belong on this list and how strongly each one fits. Its data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to the category the list is about. Each row is rated strong evidence when the company's own description names biotech startups, partial evidence when it names part of the category, and indirect evidence when the description shown names none of it and the match rests on the rest of the company's profile.

How many biotech startups are there based in the United States?

RevenueBase identified 692 biotech startups headquartered in the United States as of September 2026, matched on each company's own description of what it does rather than its industry code.

What is the largest company on this list?

Aldevron, headquartered in Fargo, tops this list with the largest team on record.

Which city has the most biotech startups?

San Francisco leads with 46 headquartered companies, followed by Boston (41) and New York (33).

How do I get contact information for these companies?

A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 3,510 verified decision-maker contacts tracked across these 692 companies.

How current is this list?

The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 16, 2026.

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About this data

RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase Smart Search, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.