Company lists · Data refreshed September 2026

Top 25 Small molecule manufacturers based in the United States

Name: Small molecule manufacturers based in the United States
Creator: RevenueBase
License: https://creativecommons.org/licenses/by/4.0/

Compiled by the RevenueBase Data Team Data refreshed Sep 18, 2026 506 companies tracked

RevenueBase identified 506 small molecule manufacturers headquartered in the United States as of September 2026 and tracks 103,951 professional contacts across them, including 44,101 with verified work emails. San Diego is the largest hub.

This list covers small molecule manufacturers headquartered in the United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, its RevenueBase Smart Search rating, and when it was last checked. Data refreshed September 18, 2026.

Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase Smart Search, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.

How to read this list HQ checked on every row RevenueBase Smart Search rating on every row Refreshed Sep 18, 2026 86% judged on-target in blind review

506Companies

103,951Contacts tracked

44,101Verified emails

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The 25 largest small molecule manufacturers based in the United States

Ranked by team size

Top 25 of 506 small molecule manufacturers based in the United States, ranked by team size, largest first. Data refreshed Sep 18, 2026. RevenueBase Smart Search rates how each company's information relates to small molecule manufacturers: strong evidence (its own description names it), partial (names part of it), indirect (matched on the rest of its profile rather than the description shown). Click a contact count to view that company's people.
#	Company	RevenueBase Smart Search	Headquarters	Employees	Contacts
1	AMGEN	Indirect evidence	Thousand Oaks, CA, United StatesHQ checked Sep 18, 2026	10001+	33,433 contacts →
	Indirect evidence “Amgen harnesses the best of biology and technology to fight the world’s toughest diseases, and make people’s lives easier, fuller and longer.” Source: RevenueBase Database · checked Sep 18, 2026
2	Genentech	Indirect evidence	South San Francisco, CA, United StatesHQ checked Sep 18, 2026	10001+	17,217 contacts →
	Indirect evidence “About Genentech We're passionate about finding solutions for people facing the world's most difficult-to-treat conditions.” Source: RevenueBase Database · checked Sep 18, 2026
3	Biogen	Indirect evidence	Cambridge, MA, United StatesHQ checked Sep 18, 2026	5,001-10,000	10,389 contacts →
	Indirect evidence “Founded in 1978, Biogen is a leading biotechnology company that pioneers innovative science to deliver new medicines to transform patients’ lives and to create value for…” Source: RevenueBase Database · checked Sep 18, 2026
4	Lupin Pharmaceuticals	Indirect evidence	Somerset, NJ, United StatesHQ checked Sep 18, 2026	n/a	4,649 contacts →
	Indirect evidence “Lupin Pharmaceuticals, Inc.” Source: RevenueBase Database · checked Sep 18, 2026
5	Daiichi Sankyo US	Indirect evidence	Basking Ridge, NJ, United StatesHQ checked Sep 18, 2026	10001+	3,973 contacts →
	Indirect evidence “At Daiichi Sankyo, we create essential medicine for longer, better lives.” Source: RevenueBase Database · checked Sep 18, 2026
6	Eisai US	Indirect evidence	Nutley, NJ, United StatesHQ checked Sep 18, 2026	1,001-5,000	2,570 contacts →
	Indirect evidence “At Eisai Inc, human health care (hhc) is our goal.” Source: RevenueBase Database · checked Sep 18, 2026
7	Legend Biotech	Indirect evidence	Somerset, NJ, United StatesHQ checked Sep 18, 2026	1,001-5,000	2,154 contacts →
	Indirect evidence “Legend Biotech is a global, commercial-stage biotechnology company developing and manufacturing novel therapies.” Source: RevenueBase Database · checked Sep 18, 2026
8	Beigene	Indirect evidence	Cambridge, MA, United StatesHQ checked Sep 18, 2026	n/a	2,135 contacts →
	Indirect evidence “Effective March 17, 2025, The U.S.” Source: RevenueBase Database · checked Sep 18, 2026
9	Celgene	Indirect evidence	Summit, NJ, United StatesHQ checked Sep 18, 2026	5,001-10,000	2,098 contacts →
	Indirect evidence “We have merged with Bristol Myers Squibb creating a leading biopharma company, ideally positioned to discover, develop and deliver innovative medicines for patients fighting…” Source: RevenueBase Database · checked Sep 18, 2026
10	Valeant Pharmaceuticals	Indirect evidence	Bridgewater, NJ, United StatesHQ checked Sep 18, 2026	10001+	1,121 contacts →
	Indirect evidence Source: RevenueBase Database · checked Sep 18, 2026
11	Purdue Pharma L.P	Partial evidence	Stamford, CT, United StatesHQ checked Sep 18, 2026	501-1,000	885 contacts →
	Partial evidence “Purdue and its subsidiaries develop, manufacture and market medications to meet the evolving needs of healthcare professionals, patients, and caregivers.” Source: RevenueBase Database · checked Sep 18, 2026
12	Apellis Pharmaceuticals	Indirect evidence	Waltham, MA, United StatesHQ checked Sep 18, 2026	501-1,000	823 contacts →
	Indirect evidence “Apellis is now part of Biogen.” Source: RevenueBase Database · checked Sep 18, 2026
13	Azurity Pharmaceuticals	Indirect evidence	Woburn, MA, United StatesHQ checked Sep 18, 2026	501-1,000	790 contacts →
	Indirect evidence “Azurity Pharmaceuticals is a privately held global pharmaceutical company dedicated to redefining medicine for the real world.” Source: RevenueBase Database · checked Sep 18, 2026
14	Kyowa Kirin, Inc.- U.S	Indirect evidence	Princeton, NJ, United StatesHQ checked Sep 18, 2026	501-1,000	727 contacts →
	Indirect evidence “Kyowa Kirin is a global specialty pharmaceutical company that applies state-of-the-art biotechnologies to discover and deliver novel medicines.” Source: RevenueBase Database · checked Sep 18, 2026
15	Arrowhead Pharmaceuticals	Indirect evidence	Pasadena, CA, United StatesHQ checked Sep 18, 2026	501-1,000	657 contacts →
	Indirect evidence “Arrowhead Pharmaceuticals is a clinical stage, Nasdaq listed (ticker ARWR) company developing medicines that treat intractable diseases by silencing the genes that cause them.” Source: RevenueBase Database · checked Sep 18, 2026
16	Arcus Biosciences	Partial evidence	Hayward, CA, United StatesHQ checked Sep 18, 2026	501-1,000	632 contacts →
	Partial evidence “Arcus Biosciences is a rapidly growing, clinical-stage, global biopharmaceutical company developing differentiated molecules and combination medicines that may have the potential…” Source: RevenueBase Database · checked Sep 18, 2026
17	Akorn Pharmaceuticals	Partial evidence	Lake Forest, IL, United StatesHQ checked Sep 18, 2026	1,001-5,000	616 contacts →
	Partial evidence “At Akorn, we develop, manufacture and market specialty pharmaceuticals, including prescription, consumer health and animal health products.” Source: RevenueBase Database · checked Sep 18, 2026
18	Vanda Pharmaceuticals	Indirect evidence	Washington, DC, United StatesHQ checked Sep 18, 2026	201-500	575 contacts →
	Indirect evidence “Vanda is a leading global biopharmaceutical company focused on the development and commercialization of innovative therapies to address high unmet medical needs and improve the…” Source: RevenueBase Database · checked Sep 18, 2026
19	Ardelyx, INC	Indirect evidence	Waltham, MA, United StatesHQ checked Sep 18, 2026	201-500	497 contacts →
	Indirect evidence “Ardelyx is a commercial-stage biopharmaceutical company focused on the development and commercialization of innovative medicines that meet significant unmet medical needs.” Source: RevenueBase Database · checked Sep 18, 2026
20	Xeris Pharmaceuticals, INC	Indirect evidence	Chicago, IL, United StatesHQ checked Sep 18, 2026	201-500	481 contacts →
	Indirect evidence “We're a growth-oriented biopharmaceutical company improving patient lives by developing and commercializing advanced products across a range of therapies.” Source: RevenueBase Database · checked Sep 18, 2026
21	CV Therapeutics	Indirect evidence	Palo Alto, CA, United StatesHQ checked Sep 18, 2026	201-500	440 contacts →
	Indirect evidence “CV Therapeutics, Inc.” Source: RevenueBase Database · checked Sep 18, 2026
22	Eikon Therapeutics	Indirect evidence	Millbrae, CA, United StatesHQ checked Sep 18, 2026	201-500	423 contacts →
	Indirect evidence “Eikon Therapeutics is a late-stage clinical biopharmaceutical company advancing a pipeline of potential therapies for patients with unmet medical needs.” Source: RevenueBase Database · checked Sep 18, 2026
23	Taiho Oncology, INC	Indirect evidence	Princeton, NJ, United StatesHQ checked Sep 18, 2026	201-500	405 contacts →
	Indirect evidence “The mission of Taiho Oncology, Inc.” Source: RevenueBase Database · checked Sep 18, 2026
24	Upsher-Smith	Indirect evidence	Maple Grove, MN, United StatesHQ checked Sep 18, 2026	51-200	395 contacts →
	Indirect evidence “Upsher‑Smith is the commercial arm of the Bora Group, focused on developing, marketing, and distributing pharmaceutical products that make a real difference for patients.” Source: RevenueBase Database · checked Sep 18, 2026
25	Mirum Pharmaceuticals, INC	Indirect evidence	Foster City, CA, United StatesHQ checked Sep 18, 2026	201-500	374 contacts →
	Indirect evidence “Mirum Pharmaceuticals is a leading rare disease company with a global footprint of approved products and a broad pipeline of investigational medicines.” Source: RevenueBase Database · checked Sep 18, 2026

RevenueBase Smart Search

RevenueBase Smart Search assesses information from a company’s LinkedIn profile, information supplied directly by the company, its website, and other publicly available sources. It uses that information to rate how closely the company relates to this list’s category: small molecule manufacturers. Every row carries its rating and the description the rating was read from, so each one can be checked rather than taken on trust.

Strong evidence: The company's own public description of its business names small molecule manufacturers.
Partial evidence: Its own public description names part of small molecule manufacturers, so it works in or next to the category without describing itself that way.
Indirect evidence: The description shown does not name small molecule manufacturers. The match rests on the rest of the company's public profile rather than the one sentence quoted here, so this is the rating to check first.

RevenueBase Smart Search is how these lists are built: RevenueBase's data engine and AI assemble the companies that match a category defined in a user's own words, so a list can be about what companies actually do rather than about whichever industry code they were filed under.

Showing 25 of 506 small molecule manufacturers based in the United States

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Small molecule manufacturers based in the United States at a glance

As of Sep 18, 2026

42.4%Verified-email coverage

205.4Average contacts per company

11-50Median size (employees)

5.9%Largest-city concentration · San Diego

Sep 18, 2026Page data refreshed

Companies by employee count

1-10

182

11-50

167

51-200

201-500

501-1,000

1,001-5,000

5,001-10,000

10001+

Email recency for this list is measured worldwide rather than for United States, so it is reported there. Company counts and contact totals on this page are exact for United States, over 506 companies.

How this list was built

Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among small molecule manufacturers, so some rows will be adjacent to the category rather than pure plays. The description and RevenueBase Smart Search rating on every row are there so you can check each match yourself.

Source: The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase Smart Search, the natural-language company search available to every RevenueBase user.
What qualifies: Companies headquartered in the United States whose own description of what they do matches “small molecule manufacturers”. Matching reads each company's description, not its industry code or its name.
RevenueBase Smart Search: RevenueBase Smart Search is how this list is assembled and how each row is rated. RevenueBase's data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to a category defined in a user's own words. Each row is rated strong evidence (its own description names small molecule manufacturers), partial evidence (it names part of the category) or indirect evidence (the description shown names none of it and the match rests on the rest of the company's profile). The description supporting each rating is quoted on the row.
What we exclude: Companies whose own description does not clearly place them among small molecule manufacturers, and records with no verified work email. Companies headquartered outside United States are excluded even when they keep an office there.
Match quality: In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and its RevenueBase Smart Search rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
Ranking: Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
Verification: Every listed company carries at least one verified work email, 44,101 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
Refresh: This page's figures were pulled from the company graph on September 18, 2026. Lists refresh periodically as the graph is re-checked.
Corrections: Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.

Small molecule manufacturers by metro

Small molecule manufacturers in San Diego30

Frequently asked

What is RevenueBase Smart Search?

RevenueBase Smart Search is how RevenueBase decides which companies belong on this list and how strongly each one fits. Its data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to the category the list is about. Each row is rated strong evidence when the company's own description names small molecule manufacturers, partial evidence when it names part of the category, and indirect evidence when the description shown names none of it and the match rests on the rest of the company's profile.

How many small molecule manufacturers are there based in the United States?

RevenueBase identified 506 small molecule manufacturers headquartered in the United States as of September 2026, matched on each company's own description of what it does rather than its industry code.

What is the largest company on this list?

AMGEN, headquartered in Thousand Oaks, tops this list with the largest team on record.

Which city has the most small molecule manufacturers?

San Diego leads with 30 headquartered companies, followed by Cambridge (18) and Boston (12).

How do I get contact information for these companies?

A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 44,101 verified decision-maker contacts tracked across these 506 companies.

How current is this list?

The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 18, 2026.

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About this data

RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase Smart Search, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.