Company lists · Data refreshed September 2026

Top 24 Scientific computing software companies based in the United States

RevenueBase identified 59 scientific computing software companies headquartered in the United States as of September 2026 and tracks 9,436 professional contacts across them, including 4,782 with verified work emails. San Diego is the largest hub.

This list covers scientific computing software companies headquartered in the United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, its RevenueBase Smart Search rating, and when it was last checked. Data refreshed September 29, 2026.

Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase Smart Search, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.

How to read this list HQ checked on every row RevenueBase Smart Search rating on every row Refreshed Sep 29, 2026 86% judged on-target in blind review
59Companies
9,436Contacts tracked
4,782Verified emails
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The 24 largest scientific computing software companies based in the United States

Ranked by team size
Top 24 of 59 scientific computing software companies based in the United States, ranked by team size, largest first. Data refreshed Sep 29, 2026. RevenueBase Smart Search rates how each company's information relates to scientific computing software companies: strong evidence (its own description names it), partial (names part of it), indirect (matched on the rest of its profile rather than the description shown). Click a contact count to view that company's people.
#CompanyRevenueBase Smart SearchHeadquartersEmployeesContacts
1Strong evidenceNatick, MA, United StatesHQ checked Sep 29, 20265,001-10,0006,694 contacts →

Strong evidence

“MathWorks is the leading developer of mathematical computing software.”

Source: RevenueBase Database · checked Sep 29, 2026
2Partial evidenceCary, NC, United StatesHQ checked Sep 29, 2026201-500557 contacts →

Partial evidence

“Great software in the right hands can change the world.”

Source: RevenueBase Database · checked Sep 29, 2026
3Strong evidenceChampaign, IL, United StatesHQ checked Sep 29, 2026501-1,000551 contacts →

Strong evidence

“Founded by Stephen Wolfram in 1987, Wolfram Research is one of the world's most respected computer, web, and cloud software companies-as well as a powerhouse of scientific and…”

Source: RevenueBase Database · checked Sep 29, 2026
4Partial evidenceBurlington, MA, United StatesHQ checked Sep 29, 2026501-1,000521 contacts →

Partial evidence

“COMSOL develops mathematical modeling software for driving new breakthroughs in physics and engineering.”

Source: RevenueBase Database · checked Sep 29, 2026
5Strong evidenceBoston, MA, United StatesHQ checked Sep 29, 2026501-1,000405 contacts →

Strong evidence

“Dotmatics is the global leader in R&D scientific software that connects science, data, and decision-making.”

Source: RevenueBase Database · checked Sep 29, 2026
6Partial evidenceCambridge, MA, United StatesHQ checked Sep 29, 202651-20097 contacts →

Partial evidence

“JuliaHub’s mission is to empower those tackling the world’s toughest scientific and technical challenges with cutting-edge tools in a seamless, secure environment.”

Source: RevenueBase Database · checked Sep 29, 2026
7Strong evidenceAustin, TX, United StatesHQ checked Sep 29, 202651-20072 contacts →

Strong evidence

“Enthought has been at the forefront of scientific computing for 25 years with a legacy that includes pioneering the open-source scientific Python ecosystem, helping define modern…”

Source: RevenueBase Database · checked Sep 29, 2026
8Partial evidenceBellevue, WA, United StatesHQ checked Sep 29, 202651-20062 contacts →

Partial evidence

“The first general purpose computational physics software with a fully adaptive architecture.”

Source: RevenueBase Database · checked Sep 29, 2026
9Strong evidenceHillsborough, NJ, United StatesHQ checked Sep 29, 202611-5020 contacts →

Strong evidence

“DeltaSoft has been providing scientific software and expert services for research companies since 1996.”

Source: RevenueBase Database · checked Sep 29, 2026
10Partial evidencePalo Alto, CA, United StatesHQ checked Sep 29, 202651-20015 contacts →

Partial evidence

“We are a team of passionate scientists and engineers at Grafiti LLC, dedicated to developing cutting-edge software solutions that empower researchers to analyze, visualize, and…”

Source: RevenueBase Database · checked Sep 29, 2026
11Partial evidenceBoulder, CO, United StatesHQ checked Sep 29, 202611-5015 contacts →

Partial evidence

“Tech-X Corporation specializes in high-performance computational software.”

Source: RevenueBase Database · checked Sep 29, 2026
12Strong evidenceTroy, MI, United StatesHQ checked Sep 29, 202651-2009 contacts →

Strong evidence

“Altair is a global technology company that provides software and cloud solutions in the areas of product development, high performance computing (HPC) and data intelligence.”

Source: RevenueBase Database · checked Sep 29, 2026
13Indirect evidenceGreenville, NC, United StatesHQ checked Sep 29, 202611-508 contacts →

Indirect evidence

Source: RevenueBase Database · checked Sep 29, 2026
14Partial evidenceSan Diego, CA, United StatesHQ checked Sep 29, 202611-507 contacts →

Partial evidence

“GraphPad Prism provides researchers worldwide with purpose-built tools to save time, simplify data analysis, and elegantly graph and present your scientific research.”

Source: RevenueBase Database · checked Sep 29, 2026
15Indirect evidenceWalnut Creek, CA, United StatesHQ checked Sep 29, 202611-507 contacts →

Indirect evidence

“Mat3ra.com (formerly Exabyte.io) is a technology startup company based in San Francisco, California developing a novel way to design and discover advanced materials through…”

Source: RevenueBase Database · checked Sep 29, 2026
16Partial evidenceAtlanta, GA, United StatesHQ checked Sep 29, 202611-506 contacts →

Partial evidence

“ArrayFire develops and markets fast, simple GPU and accelerator software.”

Source: RevenueBase Database · checked Sep 29, 2026
17Indirect evidenceAustin, TX, United StatesHQ checked Sep 29, 202611-506 contacts →

Indirect evidence

Source: RevenueBase Database · checked Sep 29, 2026
18Partial evidenceAlpharetta, GA, United StatesHQ checked Sep 29, 202611-504 contacts →

Partial evidence

“Consulting and production of the scientiic and technical software.”

Source: RevenueBase Database · checked Sep 29, 2026
19Partial evidenceChampaign, IL, United StatesHQ checked Sep 29, 202611-504 contacts →

Partial evidence

“Illinois Rocstar LLC drives innovation in multiphysics modeling and simulation through custom software development as well as integration of external proven solutions.”

Source: RevenueBase Database · checked Sep 29, 2026
20Indirect evidenceBrookline, MA, United StatesHQ checked Sep 29, 20261-103 contacts →

Indirect evidence

“We develop computational tools to bridge the gap between high-performance and ease-of-use across a range of domains, particularly life sciences and bioinformatics.”

Source: RevenueBase Database · checked Sep 29, 2026
21Partial evidenceBoston, United StatesHQ checked Sep 29, 20261-102 contacts →

Partial evidence

“Advanced development of quantitative mathematical software for business intelligence, financial modeling, computational analytics, and multivariable control system optimization.”

Source: RevenueBase Database · checked Sep 29, 2026
22Strong evidenceSeattle, WA, United StatesHQ checked Sep 29, 20261-101 contacts →

Strong evidence

“Custom scientific software design and development.”

Source: RevenueBase Database · checked Sep 29, 2026
23Strong evidenceDurham, NC, United StatesHQ checked Sep 29, 20261-101 contacts →

Strong evidence

“Sean McGovern, PhD (Uni Bonn) provides scientific software consulting services to clients in the fields of mathematical modeling, high-performance computing, scientific computing…”

Source: RevenueBase Database · checked Sep 29, 2026
24Strong evidenceFort Collins, CO, United StatesHQ checked Sep 29, 20261-101 contacts →

Strong evidence

“We develop custom software for scientific, research, and technological applications.”

Source: RevenueBase Database · checked Sep 29, 2026

Showing 24 of 59 scientific computing software companies based in the United States

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Scientific computing software companies based in the United States at a glance

As of Sep 29, 2026
50.7%Verified-email coverage
159.9Average contacts per company
1-10Median size (employees)
6.8%Largest-city concentration · San Diego
Sep 29, 2026Page data refreshed

Companies by employee count

1-10
30
11-50
14
51-200
9
201-500
2
501-1,000
3
5,001-10,000
1

Email recency for this list is measured worldwide rather than for United States, so it is reported there. Company counts and contact totals on this page are exact for United States, over 59 companies.

How this list was built

Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among scientific computing software companies, so some rows will be adjacent to the category rather than pure plays. The description and RevenueBase Smart Search rating on every row are there so you can check each match yourself.

Source
The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase Smart Search, the natural-language company search available to every RevenueBase user.
What qualifies
Companies headquartered in the United States whose own description of what they do matches “scientific computing software companies”. Matching reads each company's description, not its industry code or its name.
RevenueBase Smart Search
RevenueBase Smart Search is how this list is assembled and how each row is rated. RevenueBase's data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to a category defined in a user's own words. Each row is rated strong evidence (its own description names scientific computing software companies), partial evidence (it names part of the category) or indirect evidence (the description shown names none of it and the match rests on the rest of the company's profile). The description supporting each rating is quoted on the row.
What we exclude
Companies whose own description does not clearly place them among scientific computing software companies, and records with no verified work email. Companies headquartered outside United States are excluded even when they keep an office there.
Match quality
In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and its RevenueBase Smart Search rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
Ranking
Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
Verification
Every listed company carries at least one verified work email, 4,782 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
Refresh
This page's figures were pulled from the company graph on September 29, 2026. Lists refresh periodically as the graph is re-checked.
Corrections
Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.

Frequently asked

What is RevenueBase Smart Search?

RevenueBase Smart Search is how RevenueBase decides which companies belong on this list and how strongly each one fits. Its data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to the category the list is about. Each row is rated strong evidence when the company's own description names scientific computing software companies, partial evidence when it names part of the category, and indirect evidence when the description shown names none of it and the match rests on the rest of the company's profile.

How many scientific computing software companies are there based in the United States?

RevenueBase identified 59 scientific computing software companies headquartered in the United States as of September 2026, matched on each company's own description of what it does rather than its industry code.

What is the largest company on this list?

Mathworks, headquartered in Natick, tops this list with the largest team on record.

Which city has the most scientific computing software companies?

San Diego leads with 4 headquartered companies, followed by Atlanta (2) and Austin (2).

How do I get contact information for these companies?

A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 4,782 verified decision-maker contacts tracked across these 59 companies.

How current is this list?

The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 29, 2026.

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About this data

RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase Smart Search, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.