Company lists · Data refreshed September 2026

Top 25 Responsible AI companies based in San Francisco, United States

RevenueBase identified 135 responsible AI companies headquartered in San Francisco, United States as of September 2026 and tracks 22,187 professional contacts across them, including 6,579 with verified work emails. New York is the largest hub.

This list covers responsible AI companies headquartered in San Francisco, United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, how directly it supports the match, and when it was last checked. Data refreshed September 5, 2026.

Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase SmartSearch, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.

How to read this list HQ checked on every row Match evidence on every row Refreshed Sep 5, 2026 86% judged on-target in blind review
135Companies
22,187Contacts tracked
6,579Verified emails
Explore all 135 companies → Free signup · no credit card · 500 free credits

The 25 largest responsible AI companies based in San Francisco, United States

Ranked by team size
Top 25 of 135 responsible AI companies based in San Francisco, United States, ranked by team size, largest first. Data refreshed Sep 5, 2026. Evidence rates how directly each company's own description names responsible AI companies: strong (names it), partial (names part of it), indirect (matched on its full profile rather than the summary shown). Click a count to unlock that company's people.
#CompanyHeadquartersEmployeesContacts
1
OpenaiPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 20261,001-5,0007,563

“OpenAI is an AI research and deployment company dedicated to ensuring that general-purpose artificial intelligence benefits all of humanity.”

Source: company website · checked Sep 5, 2026
2
Scale AIPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 2026n/a6,133

“Scale’s mission is to develop reliable AI systems for the world’s most important decisions.”

Source: company website · checked Sep 5, 2026
3
TuringPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 20261,001-5,0006,094

“Turing is one of the world’s fastest-growing AI companies accelerating the advancement and deployment of powerful AI systems.”

Source: company website · checked Sep 5, 2026
4
ProvectusPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 2026201-500434

“Provectus is an AI professional services vendor built to be the most outcomes-centric partner for your AI transformation.”

Source: company website · checked Sep 5, 2026
5
Ai4allPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 2026n/a290

“AI4ALL is an award-winning nonprofit committed to ensuring AI benefits humanity.”

Source: company website · checked Sep 5, 2026
6
DistylPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202651-200118

“Distyl partners with the most ambitious enterprises to design and operationalize their AI transformations.”

Source: company website · checked Sep 5, 2026
7
Holistic AIPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202611-5069

“Holistic AI is the control layer for enterprise AI.”

Source: company website · checked Sep 5, 2026
8
INTUZPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202651-20067

“Intuz develops AI solutions that go directly into production, not just presentations.”

Source: company website · checked Sep 5, 2026
9
BigeyePartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202611-5062

AI is only as good as the data it runs on.”

Source: company website · checked Sep 5, 2026
10
TheagenticPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202651-20056

“The next generation of AI won't be built by five companies.”

Source: company website · checked Sep 5, 2026
11
Dynamo AIPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202651-20050

“Security, hallucination, and compliance gaps are stifling your AI production goals.”

Source: company website · checked Sep 5, 2026
12
Fractional AIPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202651-20050

“Fractional AI is focused on putting frontier AI to work.”

Source: company website · checked Sep 5, 2026
13
SpeakeasyPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202611-5044

“The enterprise control plane for AI.”

Source: company website · checked Sep 5, 2026
14
Opaque SystemsPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202611-5037

AI is driving a massive platform shift, but like every major shift (PC, mobile, cloud), it demands a trust layer upgrade.”

Source: company website · checked Sep 5, 2026
15
SimplaiPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202611-5037

“SimplAI is a full-stack Agentic AI Operating System built for enterprises that need to move beyond isolated LLM experiments and deploy AI that actually runs production workflows.”

Source: company website · checked Sep 5, 2026
16
Maxim AIPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202611-5034

“At Maxim AI, we are building the production infrastructure for AI.”

Source: company website · checked Sep 5, 2026
17
Prime IntellectPartial evidence
San Francisco, United StatesHQ checked Sep 5, 202611-5034

“Prime Intellect makes frontier AI training accessible to every company.”

Source: company website · checked Sep 5, 2026
18
Virtue AIPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202611-5028

“Virtue AI sets the standard for advanced AI security platforms.”

Source: company website · checked Sep 5, 2026
19
Turium AIPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202651-20026

“Turium offers the world's first secure, private, and the most powerful version of Enterprise AI.”

Source: company website · checked Sep 5, 2026
20
OpenlayerPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202611-5024

“Openlayer is the AI Governance Control Plane for Regulated Enterprises.”

Source: company website · checked Sep 5, 2026
21
TranslucePartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 20261-1019

“Transluce is an independent research lab that builds open, scalable technology for understanding AI systems and steering them in the public interest.”

Source: company website · checked Sep 5, 2026
22
Sensfix INCPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202611-5019

“Sensfix is an agentic AI platform for buildings & facilities using multi-modal AI to digitize diverse inputs, automate workflows & run unmanned decision-making in logistics…”

Source: company website · checked Sep 5, 2026
23
APRESIndirect evidence
San Francisco, CA, United StatesHQ checked Sep 5, 20261-1013

“Founded in March 2018.”

Source: company website · checked Sep 5, 2026
24
Trussed AIPartial evidence
San Francisco, CA, United StatesHQ checked Sep 5, 202611-509

“Trussed AI is the AI control plane that enforces policy at execution time across every AI request and response.”

Source: company website · checked Sep 5, 2026
25
RuvivoIndirect evidence
San Francisco, CA, United StatesHQ checked Sep 5, 2026201-5008

“Artificial Intellegence for the Real World!”

Source: company website · checked Sep 5, 2026

Showing 25 of 135 responsible AI companies based in San Francisco, United States

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Responsible AI companies based in San Francisco, United States at a glance

As of Sep 5, 2026
1-10Median size (employees)
New YorkLargest hub · 143 HQs
Contacts with mobile numbers
Sep 5, 2026Data refreshed

Companies by employee count

1-10
70
11-50
47
51-200
12
201-500
2
501-1,000
2
1,001-5,000
2

Email recency for this list is measured across the whole United States list rather than this city, so it is reported there. Company counts and contact totals on this page are exact for San Francisco, over 135 companies.

How this list was built

Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among responsible AI companies, so some rows will be adjacent to the category rather than pure plays. The description and evidence rating on every row are there so you can check each match yourself.

Source
The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase SmartSearch, the natural-language company search available to every RevenueBase user.
What qualifies
Companies headquartered in San Francisco, United States whose own description of what they do matches “responsible AI companies”. Matching reads each company's description, not its industry code or its name.
What we exclude
Companies whose own description does not clearly place them among responsible AI companies, and records with no verified work email. Companies headquartered outside San Francisco are excluded even when they keep an office there.
Match quality
In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and an evidence rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
Ranking
Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
Verification
Every listed company carries at least one verified work email, 6,579 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
Refresh
This page's figures were pulled from the company graph on September 5, 2026. Lists refresh periodically as the graph is re-checked.
Corrections
Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.

Responsible AI companies by metro in the United States

Frequently asked

How many responsible AI companies are there based in San Francisco, United States?

RevenueBase identified 135 responsible AI companies headquartered in San Francisco, United States as of September 2026, matched on each company's own description of what it does rather than its industry code.

What is the largest company on this list?

Openai, headquartered in San Francisco, tops this list with the largest team on record.

Which city has the most responsible AI companies?

New York leads with 143 headquartered companies, followed by San Francisco (135) and Austin (59).

How do I get contact information for these companies?

A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 6,579 verified decision-maker contacts tracked across these 135 companies.

How current is this list?

The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 5, 2026.

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About this data

RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase SmartSearch, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.