Company lists · Data refreshed September 2026

Top 25 Real world evidence software companies based in the United States

RevenueBase identified 452 real world evidence software companies headquartered in the United States as of September 2026 and tracks 101,397 professional contacts across them, including 44,723 with verified work emails. New York is the largest hub.

This list covers real world evidence software companies headquartered in the United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, its RevenueBase Smart Search rating, and when it was last checked. Data refreshed September 29, 2026.

Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase Smart Search, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.

How to read this list HQ checked on every row RevenueBase Smart Search rating on every row Refreshed Sep 29, 2026 86% judged on-target in blind review
452Companies
101,397Contacts tracked
44,723Verified emails
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The 25 largest real world evidence software companies based in the United States

Ranked by team size
Top 25 of 452 real world evidence software companies based in the United States, ranked by team size, largest first. Data refreshed Sep 29, 2026. RevenueBase Smart Search rates how each company's information relates to real world evidence software companies: strong evidence (its own description names it), partial (names part of it), indirect (matched on the rest of its profile rather than the description shown). Click a contact count to view that company's people.
#CompanyRevenueBase Smart SearchHeadquartersEmployeesContacts
1Indirect evidenceDurham, NC, United StatesHQ checked Sep 29, 202610001+63,824 contacts →

Indirect evidence

“IQVIA (NYSE:IQV) is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries.”

Source: RevenueBase Database · checked Sep 29, 2026
2Indirect evidencePhiladelphia, PA, United StatesHQ checked Sep 29, 20261,001-5,0003,790 contacts →

Indirect evidence

“Clario, part of Thermo Fisher Scientific, is a leading provider of endpoint data solutions to the life sciences industry.”

Source: RevenueBase Database · checked Sep 29, 2026
3Indirect evidenceBowie, MD, United StatesHQ checked Sep 29, 20261,001-5,0003,106 contacts →

Indirect evidence

“Inovalon empowers payers, providers, pharmacies, and life sciences organizations with data and solutions to drive meaningful change in patient outcomes, business performance, and…”

Source: RevenueBase Database · checked Sep 29, 2026
4Indirect evidenceNew York, NY, United StatesHQ checked Sep 29, 20261,001-5,0002,704 contacts →

Indirect evidence

“Medidata is powering smarter treatments and healthier people through digital solutions to support clinical trials.”

Source: RevenueBase Database · checked Sep 29, 2026
5Indirect evidenceBlue Bell, PA, United StatesHQ checked Sep 29, 20261,001-5,0002,083 contacts →

Indirect evidence

“For 25+ years, Signant Health has been pioneering solutions and methodologies that propel clinical research programs toward regulatory success.”

Source: RevenueBase Database · checked Sep 29, 2026
6Indirect evidenceWaltham, MA, United StatesHQ checked Sep 29, 20261,001-5,0001,864 contacts →

Indirect evidence

“Variations in care cost the healthcare industry trillions of dollars annually.”

Source: RevenueBase Database · checked Sep 29, 2026
7Partial evidenceKing Of Prussia, PA, United StatesHQ checked Sep 29, 20261,001-5,0001,858 contacts →

Partial evidence

“United BioSource LLC (UBC) is the leading provider of evidence development solutions with expertise in uniting evidence and access.”

Source: RevenueBase Database · checked Sep 29, 2026
8Indirect evidenceChicago, IL, United StatesHQ checked Sep 29, 20261,001-5,0001,645 contacts →

Indirect evidence

“Veradigm is an integrated data systems and services company that combines data-driven clinical insights with actionable tools to help healthcare stakeholders improve the quality…”

Source: RevenueBase Database · checked Sep 29, 2026
9Indirect evidencePhiladelphia, PA, United StatesHQ checked Sep 29, 20261,001-5,0001,255 contacts →

Indirect evidence

“ERT, the global clinical endpoint technology leader, and Bioclinica, a technological and scientific leader in medical imaging, is now the combined company of Clario.”

Source: RevenueBase Database · checked Sep 29, 2026
10Indirect evidenceOne Penn Plaza, NY, United StatesHQ checked Sep 29, 20261,001-5,0001,163 contacts →

Indirect evidence

“Norstella is the AI company for biopharma's highest-stakes decisions.”

Source: RevenueBase Database · checked Sep 29, 2026
11Strong evidenceCambridge, MA, United StatesHQ checked Sep 29, 20261,001-5,000931 contacts →

Strong evidence

“ConcertAI orchestrates clinical expertise, real-world data and applied AI to deliver practical intelligence for the demands of treating oncology and other complex diseases.”

Source: RevenueBase Database · checked Sep 29, 2026
12Indirect evidenceIselin, NJ, United StatesHQ checked Sep 29, 2026501-1,000894 contacts →

Indirect evidence

“Discover how Excelra, a leader in biopharma data and analytics, uniquely blends scientific understanding with technological expertise.”

Source: RevenueBase Database · checked Sep 29, 2026
13Indirect evidenceCanton, MI, United StatesHQ checked Sep 29, 2026501-1,000876 contacts →

Indirect evidence

“MMS Holdings (MMS) is an award-winning, data-focused clinical research organization (CRO) that supports the pharmaceutical and biotech industries with a proven, scientific…”

Source: RevenueBase Database · checked Sep 29, 2026
14Indirect evidenceFramingham, MA, United StatesHQ checked Sep 29, 2026501-1,000837 contacts →

Indirect evidence

“Definitive Healthcare is the leading provider of data and analytics, focusing on the business side of healthcare.”

Source: RevenueBase Database · checked Sep 29, 2026
15Partial evidenceFramingham, MA, United StatesHQ checked Sep 29, 2026501-1,000498 contacts →

Partial evidence

“Alira Health is a global healthcare consultancy redefining evidence generation through patient partnerships.”

Source: RevenueBase Database · checked Sep 29, 2026
16Indirect evidenceNew York, NY, United StatesHQ checked Sep 29, 2026501-1,000475 contacts →

Indirect evidence

“At Citeline (a Norstella company), we are a global leader in clinical trial intelligence, data, and insights for the life sciences and pharmaceutical industries.”

Source: RevenueBase Database · checked Sep 29, 2026
17Indirect evidenceMansfield, MA, United StatesHQ checked Sep 29, 2026201-500474 contacts →

Indirect evidence

“eClinical Solutions’ industry-leading data & analytics platform, elluminate®, and biometrics services experts help biopharma researchers at large, mid-size, and emerging life…”

Source: RevenueBase Database · checked Sep 29, 2026
18Partial evidenceSouth San Francisco, CA, United StatesHQ checked Sep 29, 2026201-500415 contacts →

Partial evidence

“FDB (First Databank) creates and integrates the world’s most trusted drug knowledge that, in partnership with our customers, illuminates critical healthcare decisions.”

Source: RevenueBase Database · checked Sep 29, 2026
19Indirect evidenceIselin, NJ, United StatesHQ checked Sep 29, 2026501-1,000376 contacts →

Indirect evidence

“Ephicacy was formed in 2005 in New Jersey, US, with an objective of being a niche provider of data analytics services in supporting research and clinical trial activities in life…”

Source: RevenueBase Database · checked Sep 29, 2026
20Strong evidenceCambridge, MA, United StatesHQ checked Sep 29, 2026201-500370 contacts →

Strong evidence

“nference leverages the top academic minds, world-class researchers, and real-time access to multimodal, patient-level data to accelerate drug development innovation, generate…”

Source: RevenueBase Database · checked Sep 29, 2026
21Indirect evidenceCharlestown, MA, United StatesHQ checked Sep 29, 2026501-1,000369 contacts →

Indirect evidence

“Velsera was formed in 2023 through the shared vision of Seven Bridges and Pierian, with a mission to accelerate the discovery, development, and delivery of life-changing insights.”

Source: RevenueBase Database · checked Sep 29, 2026
22Strong evidenceBethesda, MD, United StatesHQ checked Sep 29, 2026501-1,000363 contacts →

Strong evidence

“PPD™ Evidera™ solutions empower life sciences companies to demonstrate the real-world effectiveness, safety, and value of therapies throughout their life cycle, from early…”

Source: RevenueBase Database · checked Sep 29, 2026
23Indirect evidenceHartford, CT, United StatesHQ checked Sep 29, 202610001+328 contacts →

Indirect evidence

“SCIO Health Analytics is now a part of EXL Health.”

Source: RevenueBase Database · checked Sep 29, 2026
24Indirect evidenceGroton, CT, United StatesHQ checked Sep 29, 202651-200314 contacts →

Indirect evidence

“i2e drives enterprise transformation for the life sciences industry through AI-powered portfolio and clinical intelligence solutions that power critical decision-making across…”

Source: RevenueBase Database · checked Sep 29, 2026
25Indirect evidenceWinterville, NC, United StatesHQ checked Sep 29, 2026201-500305 contacts →

Indirect evidence

“NantHealth, a member of the NantWorks ecosystem of companies, provides enterprise solutions that help businesses transform complex data into actionable insights.”

Source: RevenueBase Database · checked Sep 29, 2026

Showing 25 of 452 real world evidence software companies based in the United States

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Real world evidence software companies based in the United States at a glance

As of Sep 29, 2026
44.1%Verified-email coverage
224.3Average contacts per company
11-50Median size (employees)
5.5%Largest-city concentration · New York
Sep 29, 2026Page data refreshed

Companies by employee count

1-10
170
11-50
161
51-200
66
201-500
20
501-1,000
14
1,001-5,000
13
5,001-10,000
2
10001+
6

Email recency for this list is measured worldwide rather than for United States, so it is reported there. Company counts and contact totals on this page are exact for United States, over 452 companies.

How this list was built

Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among real world evidence software companies, so some rows will be adjacent to the category rather than pure plays. The description and RevenueBase Smart Search rating on every row are there so you can check each match yourself.

Source
The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase Smart Search, the natural-language company search available to every RevenueBase user.
What qualifies
Companies headquartered in the United States whose own description of what they do matches “real world evidence software companies”. Matching reads each company's description, not its industry code or its name.
RevenueBase Smart Search
RevenueBase Smart Search is how this list is assembled and how each row is rated. RevenueBase's data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to a category defined in a user's own words. Each row is rated strong evidence (its own description names real world evidence software companies), partial evidence (it names part of the category) or indirect evidence (the description shown names none of it and the match rests on the rest of the company's profile). The description supporting each rating is quoted on the row.
What we exclude
Companies whose own description does not clearly place them among real world evidence software companies, and records with no verified work email. Companies headquartered outside United States are excluded even when they keep an office there.
Match quality
In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and its RevenueBase Smart Search rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
Ranking
Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
Verification
Every listed company carries at least one verified work email, 44,723 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
Refresh
This page's figures were pulled from the company graph on September 29, 2026. Lists refresh periodically as the graph is re-checked.
Corrections
Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.

Real world evidence software companies by metro

Frequently asked

What is RevenueBase Smart Search?

RevenueBase Smart Search is how RevenueBase decides which companies belong on this list and how strongly each one fits. Its data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to the category the list is about. Each row is rated strong evidence when the company's own description names real world evidence software companies, partial evidence when it names part of the category, and indirect evidence when the description shown names none of it and the match rests on the rest of the company's profile.

How many real world evidence software companies are there based in the United States?

RevenueBase identified 452 real world evidence software companies headquartered in the United States as of September 2026, matched on each company's own description of what it does rather than its industry code.

What is the largest company on this list?

IQVIA, headquartered in Durham, tops this list with the largest team on record.

Which city has the most real world evidence software companies?

New York leads with 25 headquartered companies, followed by Boston (13) and San Francisco (13).

How do I get contact information for these companies?

A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 44,723 verified decision-maker contacts tracked across these 452 companies.

How current is this list?

The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 29, 2026.

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About this data

RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase Smart Search, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.