Company lists · Data refreshed September 2026

Top 25 Manufacturing execution system vendors based in the United States

Name: Manufacturing execution system vendors based in the United States
Creator: RevenueBase
License: https://creativecommons.org/licenses/by/4.0/

Compiled by the RevenueBase Data Team Data refreshed Sep 17, 2026 164 companies tracked

RevenueBase identified 164 manufacturing execution system vendors headquartered in the United States as of September 2026 and tracks 3,969 professional contacts across them, including 1,449 with verified work emails. San Jose is the largest hub.

This list covers manufacturing execution system vendors headquartered in the United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, its RevenueBase Smart Search rating, and when it was last checked. Data refreshed September 17, 2026.

Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase Smart Search, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.

How to read this list HQ checked on every row RevenueBase Smart Search rating on every row Refreshed Sep 17, 2026 86% judged on-target in blind review

164Companies

3,969Contacts tracked

1,449Verified emails

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The 25 largest manufacturing execution system vendors based in the United States

Ranked by team size

Top 25 of 164 manufacturing execution system vendors based in the United States, ranked by team size, largest first. Data refreshed Sep 17, 2026. RevenueBase Smart Search rates how each company's information relates to manufacturing execution system vendors: strong evidence (its own description names it), partial (names part of it), indirect (matched on the rest of its profile rather than the description shown). Click a contact count to view that company's people.
#	Company	RevenueBase Smart Search	Headquarters	Employees	Contacts
1	CAI Software, LLC	Indirect evidence	Lincoln, RI, United StatesHQ checked Sep 17, 2026	501-1,000	604 contacts →
	Indirect evidence “CAI Software, LLC delivers mission-critical, production-oriented software to Manufacturers and Food & Beverage producers, processors, and distributors.” Source: RevenueBase Database · checked Sep 17, 2026
2	Plex, By Rockwell Automation	Partial evidence	Troy, MI, United StatesHQ checked Sep 17, 2026	501-1,000	397 contacts →
	Partial evidence “Plex, by Rockwell Automation, is a leader in cloud-delivered smart manufacturing solutions, empowering the world's manufacturers to make awesome products.” Source: RevenueBase Database · checked Sep 17, 2026
3	CAT Squared	Strong evidence	Conway, AR, United StatesHQ checked Sep 17, 2026	n/a	325 contacts →
	Strong evidence “CAT Squared provides manufacturing execution software that helps food manufacturers turn operational complexity into clarity.” Source: RevenueBase Database · checked Sep 17, 2026
4	Enhanced Information Solutions EIS	Strong evidence	Stillwater, MN, United StatesHQ checked Sep 17, 2026	51-200	159 contacts →
	Strong evidence “Enhanced Information Solutions (EIS) is a system integrator focused on computer systems that optimize manufacturing.” Source: RevenueBase Database · checked Sep 17, 2026
5	Athena Technology Solutions	Partial evidence	Fremont, CA, United StatesHQ checked Sep 17, 2026	51-200	125 contacts →
	Partial evidence “Athena Technology Solutions provides advanced MES solutions tailored for industries such as Medical devices, Semiconductors, Discrete manufacturing, and Electronics manufacturing…” Source: RevenueBase Database · checked Sep 17, 2026
6	Proshop ERP	Strong evidence	Bellingham, WA, United StatesHQ checked Sep 17, 2026	51-200	113 contacts →
	Strong evidence “ProShop is the system of execution for precision machine shops with more than 700 shops running on ProShop today.” Source: RevenueBase Database · checked Sep 17, 2026
7	Fulcrum	Partial evidence	Minneapolis, MN, United StatesHQ checked Sep 17, 2026	51-200	85 contacts →
	Partial evidence “Fulcrum replaces ERP, MRP, and MES with a Manufacturing Software-as-a-Service (SaaS) platform, allowing small and mid-sized manufacturers to improve efficiency through workflow…” Source: RevenueBase Database · checked Sep 17, 2026
8	42q	Indirect evidence	San Jose, CA, United StatesHQ checked Sep 17, 2026	51-200	74 contacts →
	Indirect evidence “42Q, a Sanmina division, is a fully-featured, cloud-based MES solution developed by manufacturers for manufacturers.” Source: RevenueBase Database · checked Sep 17, 2026
9	CIMAC	Partial evidence	San Jose, CA, United StatesHQ checked Sep 17, 2026	11-50	68 contacts →
	Partial evidence “Manufacturing IT company specializing ERP, MES, factory connectivity solutions.” Source: RevenueBase Database · checked Sep 17, 2026
10	Vimachem	Partial evidence	Queens, United StatesHQ checked Sep 17, 2026	51-200	67 contacts →
	Partial evidence “Since 2014, Vimachem has been transforming pharmaceutical and biotech manufacturing with the AI-powered, composable Vimachem Pharma MES Platform.” Source: RevenueBase Database · checked Sep 17, 2026
11	Nysus Solutions	Strong evidence	Maumee, OH, United StatesHQ checked Sep 17, 2026	51-200	56 contacts →
	Strong evidence “Nysus Solutions is a provider of manufacturing execution software and process automation for the manufacturing industry.” Source: RevenueBase Database · checked Sep 17, 2026
12	Atomtech, INC	Indirect evidence	Clarkston, MI, United StatesHQ checked Sep 17, 2026	11-50	55 contacts →
	Indirect evidence “AtomTech was founded to provide comprehensive controls solutions for our customers, leveraging industry best practices with the latest technology.” Source: RevenueBase Database · checked Sep 17, 2026
13	Crescentone INC	Strong evidence	El Segundo, CA, United StatesHQ checked Sep 17, 2026	51-200	52 contacts →
	Strong evidence “CrescentOne is a supplier of manufacturing, supply chain and ERP systems.” Source: RevenueBase Database · checked Sep 17, 2026
14	Atachi Systems	Strong evidence	San Jose, CA, United StatesHQ checked Sep 17, 2026	11-50	52 contacts →
	Strong evidence “Atachi Systems provides discrete manufacturing companies with a seamless, cloud-based Manufacturing Execution System that reduces dependencies on infrastructure, lowers…” Source: RevenueBase Database · checked Sep 17, 2026
15	ECS Solutions, A Magnum Systems Brand	Indirect evidence	Evansville, IN, United StatesHQ checked Sep 17, 2026	11-50	50 contacts →
	Indirect evidence “ECS is committed to helping fellow industry professionals solve production challenges through fair and honest relationships.” Source: RevenueBase Database · checked Sep 17, 2026
16	Quality Manufacturing Systems, Inc. Qmsi	Indirect evidence	Lavergne, TN, United StatesHQ checked Sep 17, 2026	11-50	48 contacts →
	Indirect evidence “WE ARE A TEAM OF ENGINEERS, COMPUTER PROGRAMMERS, AND DESIGNERS DRIVEN TO MEET OUR CLIENTS GLOBAL DEMAND FOR AUTOMATION.” Source: RevenueBase Database · checked Sep 17, 2026
17	ISE	Partial evidence	Hartland, WI, United StatesHQ checked Sep 17, 2026	51-200	48 contacts →
	Partial evidence “ISE helps discrete manufacturers connect ERP planning with real-world shop floor execution.” Source: RevenueBase Database · checked Sep 17, 2026
18	Caron Engineering, INC	Partial evidence	Wells, ME, United StatesHQ checked Sep 17, 2026	11-50	39 contacts →
	Partial evidence “Caron Engineering is a leading provider of CNC process optimization, tool monitoring, and manufacturing automation technology.” Source: RevenueBase Database · checked Sep 17, 2026
19	Poms Corporation	Indirect evidence	Redmond, WA, United StatesHQ checked Sep 17, 2026	51-200	39 contacts →
	Indirect evidence “We’re not just MES.” Source: RevenueBase Database · checked Sep 17, 2026
20	SG Systems Global	Strong evidence	Dallas, TX, United StatesHQ checked Sep 17, 2026	51-200	36 contacts →
	Strong evidence “V5 MES & QMS: The Ultimate Compliance & Traceability Solution for Regulated Manufacturing At SG Systems Global, we provide cutting-edge Manufacturing Execution Systems (MES) and…” Source: RevenueBase Database · checked Sep 17, 2026
21	DDI System	Strong evidence	Sarasota, FL, United StatesHQ checked Sep 17, 2026	51-200	35 contacts →
	Strong evidence “DDI System, an Advantive company, is a mission-critical software provider for specialty manufacturing and distribution businesses.” Source: RevenueBase Database · checked Sep 17, 2026
22	Amper Technologies	Indirect evidence	Chicago, IL, United StatesHQ checked Sep 17, 2026	11-50	34 contacts →
	Indirect evidence “At Amper, we understand that your shop is more than just machines.” Source: RevenueBase Database · checked Sep 17, 2026
23	Matrix Automation	Partial evidence	Huron, OH, United StatesHQ checked Sep 17, 2026	11-50	32 contacts →
	Partial evidence “Matrix Automation optimizes assembly manufacturing with proven software and services.” Source: RevenueBase Database · checked Sep 17, 2026
24	Expandable Software, INC	Indirect evidence	San Jose, CA, United StatesHQ checked Sep 17, 2026	11-50	32 contacts →
	Indirect evidence Source: RevenueBase Database · checked Sep 17, 2026
25	Insequence Corporation	Indirect evidence	Smyrna, TN, United StatesHQ checked Sep 17, 2026	51-200	28 contacts →
	Indirect evidence “Insequence provides powerful, cutting edge software solutions to discrete manufacturers and logistics companies focused on driving shop floor activities such as Sequential Part…” Source: RevenueBase Database · checked Sep 17, 2026

RevenueBase Smart Search

RevenueBase Smart Search assesses information from a company’s LinkedIn profile, information supplied directly by the company, its website, and other publicly available sources. It uses that information to rate how closely the company relates to this list’s category: manufacturing execution system vendors. Every row carries its rating and the description the rating was read from, so each one can be checked rather than taken on trust.

Strong evidence: The company's own public description of its business names manufacturing execution system vendors.
Partial evidence: Its own public description names part of manufacturing execution system vendors, so it works in or next to the category without describing itself that way.
Indirect evidence: The description shown does not name manufacturing execution system vendors. The match rests on the rest of the company's public profile rather than the one sentence quoted here, so this is the rating to check first.

RevenueBase Smart Search is how these lists are built: RevenueBase's data engine and AI assemble the companies that match a category defined in a user's own words, so a list can be about what companies actually do rather than about whichever industry code they were filed under.

Showing 25 of 164 manufacturing execution system vendors based in the United States

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Manufacturing execution system vendors based in the United States at a glance

As of Sep 17, 2026

36.5%Verified-email coverage

24.2Average contacts per company

11-50Median size (employees)

3.0%Largest-city concentration · San Jose

Sep 17, 2026Page data refreshed

Companies by employee count

1-10

11-50

51-200

201-500

501-1,000

1,001-5,000

10001+

Email recency for this list is measured worldwide rather than for United States, so it is reported there. Company counts and contact totals on this page are exact for United States, over 164 companies.

How this list was built

Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among manufacturing execution system vendors, so some rows will be adjacent to the category rather than pure plays. The description and RevenueBase Smart Search rating on every row are there so you can check each match yourself.

Source: The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase Smart Search, the natural-language company search available to every RevenueBase user.
What qualifies: Companies headquartered in the United States whose own description of what they do matches “manufacturing execution system vendors”. Matching reads each company's description, not its industry code or its name.
RevenueBase Smart Search: RevenueBase Smart Search is how this list is assembled and how each row is rated. RevenueBase's data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to a category defined in a user's own words. Each row is rated strong evidence (its own description names manufacturing execution system vendors), partial evidence (it names part of the category) or indirect evidence (the description shown names none of it and the match rests on the rest of the company's profile). The description supporting each rating is quoted on the row.
What we exclude: Companies whose own description does not clearly place them among manufacturing execution system vendors, and records with no verified work email. Companies headquartered outside United States are excluded even when they keep an office there.
Match quality: In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and its RevenueBase Smart Search rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
Ranking: Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
Verification: Every listed company carries at least one verified work email, 1,449 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
Refresh: This page's figures were pulled from the company graph on September 17, 2026. Lists refresh periodically as the graph is re-checked.
Corrections: Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.

Frequently asked

What is RevenueBase Smart Search?

RevenueBase Smart Search is how RevenueBase decides which companies belong on this list and how strongly each one fits. Its data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to the category the list is about. Each row is rated strong evidence when the company's own description names manufacturing execution system vendors, partial evidence when it names part of the category, and indirect evidence when the description shown names none of it and the match rests on the rest of the company's profile.

How many manufacturing execution system vendors are there based in the United States?

RevenueBase identified 164 manufacturing execution system vendors headquartered in the United States as of September 2026, matched on each company's own description of what it does rather than its industry code.

What is the largest company on this list?

CAI Software, LLC, headquartered in Lincoln, tops this list with the largest team on record.

Which city has the most manufacturing execution system vendors?

San Jose leads with 5 headquartered companies, followed by Austin (4) and New York (4).

How do I get contact information for these companies?

A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 1,449 verified decision-maker contacts tracked across these 164 companies.

How current is this list?

The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 17, 2026.

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About this data

RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase Smart Search, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.