Company lists · Data refreshed September 2026
Top 25 Manufacturing execution system software companies based in the United States
RevenueBase identified 147 manufacturing execution system software companies headquartered in the United States as of September 2026 and tracks 3,227 professional contacts across them, including 1,106 with verified work emails and 1,022 with mobile numbers. San Jose is the largest hub.
This list covers manufacturing execution system software companies headquartered in the United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, how directly it supports the match, and when it was last checked. Data refreshed September 5, 2026.
Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase SmartSearch, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.
The 25 largest manufacturing execution system software companies based in the United States
Ranked by team size| # | Company | Contacts | |||
|---|---|---|---|---|---|
| 1 | 604 | ||||
“CAI Software, LLC delivers mission-critical, production-oriented software to Manufacturers and Food & Beverage producers, processors, and distributors.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 2 | 325 | ||||
“CAT Squared provides manufacturing execution software that helps food manufacturers turn operational complexity into clarity.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 3 | 159 | ||||
“Enhanced Information Solutions (EIS) is a system integrator focused on computer systems that optimize manufacturing.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 4 | 125 | ||||
“Athena Technology Solutions provides advanced MES solutions tailored for industries such as Medical devices, Semiconductors, Discrete manufacturing, and Electronics manufacturing…” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 5 | 113 | ||||
“ProShop is the system of execution for precision machine shops with more than 700 shops running on ProShop today.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 6 | 85 | ||||
“Fulcrum replaces ERP, MRP, and MES with a Manufacturing Software-as-a-Service (SaaS) platform, allowing small and mid-sized manufacturers to improve efficiency through workflow…” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 7 | 74 | ||||
“42Q, a Sanmina division, is a fully-featured, cloud-based MES solution developed by manufacturers for manufacturers.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 8 | 68 | ||||
“Manufacturing IT company specializing ERP, MES, factory connectivity solutions.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 9 | VimachemPartial evidence | 67 | |||
“Since 2014, Vimachem has been transforming pharmaceutical and biotech manufacturing with the AI-powered, composable Vimachem Pharma MES Platform.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 10 | 56 | ||||
“Nysus Solutions is a provider of manufacturing execution software and process automation for the manufacturing industry.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 11 | 52 | ||||
“Are you looking for an out-of-the-box manufacturing ERP solution that adapts to your business processes?” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 12 | 52 | ||||
“CrescentOne is a supplier of manufacturing, supply chain and ERP systems.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 13 | 52 | ||||
“Atachi Systems provides discrete manufacturing companies with a seamless, cloud-based Manufacturing Execution System that reduces dependencies on infrastructure, lowers…” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 14 | 48 | ||||
“First Resonance builds the ION Factory OS, the leading Factory OS powering leading manufacturers in aviation, energy, automotive, and more.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 15 | Quality Manufacturing Systems, Inc. QmsiIndirect evidence | 48 | |||
“WE ARE A TEAM OF ENGINEERS, COMPUTER PROGRAMMERS, AND DESIGNERS DRIVEN TO MEET OUR CLIENTS GLOBAL DEMAND FOR AUTOMATION.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 16 | 39 | ||||
“We’re not just MES.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 17 | SG Systems GlobalStrong evidence | 36 | |||
“V5 MES & QMS: The Ultimate Compliance & Traceability Solution for Regulated Manufacturing At SG Systems Global, we provide cutting-edge Manufacturing Execution Systems (MES) and…” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 18 | 35 | ||||
“DDI System, an Advantive company, is a mission-critical software provider for specialty manufacturing and distribution businesses.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 19 | 34 | ||||
“At Amper, we understand that your shop is more than just machines.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 20 | 32 | ||||
Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 21 | 28 | ||||
“Insequence provides powerful, cutting edge software solutions to discrete manufacturers and logistics companies focused on driving shop floor activities such as Sequential Part…” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 22 | 27 | ||||
“Cumulus Consulting is the largest and most qualified implementation partner to assist you with your Plex MES/ERP, Custom Development, and Machine Integration projects.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 23 | 25 | ||||
“EZSoft is a leading provider of Information and Control Systems for the process industries.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 24 | MANEXPartial evidence | 24 | |||
“Manex builds ERP and MES software purpose-built for electronics contract manufacturers.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
| 25 | 23 | ||||
“Jobscope is a leading provider of manufacturing ERP software & services, helping order-driven businesses improve operational performance & increase revenue.” Source: company website · checked Sep 5, 2026Thanks. The Data Team will review it. | |||||
Showing 25 of 147 manufacturing execution system software companies based in the United States
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Manufacturing execution system software companies based in the United States at a glance
As of Sep 5, 2026Companies by employee count
Verified emails by last verification
How this list was built
Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among manufacturing execution system software companies, so some rows will be adjacent to the category rather than pure plays. The description and evidence rating on every row are there so you can check each match yourself.
- Source
- The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase SmartSearch, the natural-language company search available to every RevenueBase user.
- What qualifies
- Companies headquartered in the United States whose own description of what they do matches “manufacturing execution system software companies”. Matching reads each company's description, not its industry code or its name.
- What we exclude
- Companies whose own description does not clearly place them among manufacturing execution system software companies, and records with no verified work email. Companies headquartered outside United States are excluded even when they keep an office there.
- Match quality
- In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and an evidence rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
- Ranking
- Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
- Verification
- Every listed company carries at least one verified work email, 1,106 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
- Refresh
- This page's figures were pulled from the company graph on September 5, 2026. Lists refresh periodically as the graph is re-checked.
- Corrections
- Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.
Frequently asked
How many manufacturing execution system software companies are there based in the United States?
RevenueBase identified 147 manufacturing execution system software companies headquartered in the United States as of September 2026, matched on each company's own description of what it does rather than its industry code.
What is the largest company on this list?
CAI Software, LLC, headquartered in Lincoln, tops this list with the largest team on record.
Which city has the most manufacturing execution system software companies?
San Jose leads with 5 headquartered companies, followed by Austin (4) and New York (4).
How do I get contact information for these companies?
A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 1,106 verified decision-maker contacts tracked across these 147 companies.
How current is this list?
The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 5, 2026.
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About this data
RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase SmartSearch, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.
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