Company lists · Data refreshed September 2026

Top 25 Healthcare middleware software companies based in the United States

Name: Healthcare middleware software companies based in the United States
Creator: RevenueBase
License: https://creativecommons.org/licenses/by/4.0/

Compiled by the RevenueBase Data Team Data refreshed Sep 3, 2026 1,199 companies tracked

RevenueBase identified 1,199 healthcare middleware software companies headquartered in the United States as of September 2026 and tracks 55,922 professional contacts across them, including 23,727 with verified work emails and 19,910 with mobile numbers. New York is the largest hub.

This list covers healthcare middleware software companies headquartered in the United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, how directly it supports the match, and when it was last checked. Data refreshed September 3, 2026.

Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase SmartSearch, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.

How to read this list HQ checked on every row Match evidence on every row Refreshed Sep 3, 2026 86% judged on-target in blind review

1,199Companies

55,922Contacts tracked

23,727Verified emails

19,910Mobile numbers

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The 25 largest healthcare middleware software companies based in the United States

Ranked by team size

Top 25 of 1,199 healthcare middleware software companies based in the United States, ranked by team size, largest first. Data refreshed Sep 3, 2026. Evidence rates how directly each company's own description names healthcare middleware software companies: strong (names it), partial (names part of it), indirect (matched on its full profile rather than the summary shown). Click a count to unlock that company's people.
#	Company	Headquarters	Employees	Contacts
1	EclinicalworksPartial evidence	Westborough, CA, United StatesHQ checked Sep 3, 2026	5,001-10,000	5,251
	“eClinicalWorks is a privately held leader in healthcare IT, providing comprehensive Electronic Health Record (EHR) and Practice Management (PM) solutions used by more than medical…” Source: company website · checked Sep 3, 2026
2	NetsmartPartial evidence	Overland Park, IL, United StatesHQ checked Sep 3, 2026	1,001-5,000	2,457
	“Netsmart is an industry-leading healthcare technology organization dedicated to empowering providers to deliver value-based care to individuals and communities.” Source: company website · checked Sep 3, 2026
3	WellskyPartial evidence	Overland Park, KS, United StatesHQ checked Sep 3, 2026	1,001-5,000	2,000
	“WellSky is one of America’s largest and most innovative healthcare technology companies leading the movement for intelligent, coordinated care.” Source: company website · checked Sep 3, 2026
4	ModmedIndirect evidence	Boca Raton, FL, United StatesHQ checked Sep 3, 2026	1,001-5,000	1,752
	“At ModMed, we empower medical practices to grow and scale by delivering better patient experiences with cloud, data and AI technologies.” Source: company website · checked Sep 3, 2026
5	GHXStrong evidence	Denver, CO, United StatesHQ checked Sep 3, 2026	1,001-5,000	1,678
	“GHX is a software-as-a-service company that’s reducing the cost of doing business in healthcare by automating supply chain processes and improving visibility into the products…” Source: company website · checked Sep 3, 2026
6	PhreesiaIndirect evidence	Wilmington, DE, United StatesHQ checked Sep 3, 2026	1,001-5,000	1,651
	“Phreesia was founded in 2005 to help patients take an active role in their care.” Source: company website · checked Sep 3, 2026
7	WaystarStrong evidence	Louisville, KS, United StatesHQ checked Sep 3, 2026	1,001-5,000	1,619
	“Waystar’s enterprise-grade software is purpose-built to simplify healthcare payments.” Source: company website · checked Sep 3, 2026
8	Carenet HealthPartial evidence	San Antonio, TX, United StatesHQ checked Sep 3, 2026	1,001-5,000	1,602
	“Carenet Health is committed to delivering the business of healthcare through leading-edge technology, unmatched perspective and insights, and operational excellence to help…” Source: company website · checked Sep 3, 2026
9	SharecareStrong evidence	Atlanta, GA, United StatesHQ checked Sep 3, 2026	1,001-5,000	1,198
	“Sharecare is a digital healthcare company that delivers software and tech-enabled services to stakeholders across the healthcare ecosystem to help improve care quality, drive…” Source: company website · checked Sep 3, 2026
10	Trizetto Healthcare ProductsIndirect evidence	Teaneck, CO, United StatesHQ checked Sep 3, 2026	10001+	995
	“Cognizant (Nasdaq-100: CTSH) is one of the world's leading professional services companies, transforming clients' business, operating and technology models for the digital era.” Source: company website · checked Sep 3, 2026
11	Simplify HealthcarePartial evidence	Aurora, IL, United StatesHQ checked Sep 3, 2026	501-1,000	960
	“Healthcare technology company providing cloud-based AI-powered SaaS solutions for health insurance payers.” Source: company website · checked Sep 3, 2026
12	Healthcare Management SystemsPartial evidence	Franklin, TN, United StatesHQ checked Sep 3, 2026	501-1,000	903
	“Healthcare Management Systems, Inc.(HMS) is a Nashville-based healthcare company that develops, sells, and supports integrated clinical and financial hospital information systems…” Source: company website · checked Sep 3, 2026
13	CPSIPartial evidence	Emanuel, AL, United StatesHQ checked Sep 3, 2026	1,001-5,000	850
	“CPSI is a leading provider of healthcare solutions and services for community hospitals, their clinics and post-acute care facilities.” Source: company website · checked Sep 3, 2026
14	EdifecsIndirect evidence	Bellevue, WA, United StatesHQ checked Sep 3, 2026	1,001-5,000	808
	“Edifecs, a Cotiviti business, provides market-leading technology to its payer and health system customers, which serve nearly 300 million people in the U.S.” Source: company website · checked Sep 3, 2026
15	SurescriptsPartial evidence	Arlington, NC, United StatesHQ checked Sep 3, 2026	501-1,000	712
	“At Surescripts, we bring healthcare together to inform and accelerate decisions, helping keep patient care on track.” Source: company website · checked Sep 3, 2026
16	Centauri Health Solutions, INCIndirect evidence	Tempe, OH, United StatesHQ checked Sep 3, 2026	1,001-5,000	609
	“Centauri Health Solutions aims to attract and retain the industry’s top talent as we continue to create and deliver the most flexible and innovative tools in the market.” Source: company website · checked Sep 3, 2026
17	Nomad HealthPartial evidence	New York, NY, United StatesHQ checked Sep 3, 2026	501-1,000	606
	“Nomad Health is the AI-native System of Action for healthcare staffing firms.” Source: company website · checked Sep 3, 2026
18	EllkayPartial evidence	Elmwood Park, NJ, United StatesHQ checked Sep 3, 2026	501-1,000	577
	“ELLKAY is a trusted enterprise data management partner, driving innovation and connectivity across the healthcare ecosystem.” Source: company website · checked Sep 3, 2026
19	NET HealthPartial evidence	Pittsburgh, PA, United StatesHQ checked Sep 3, 2026	501-1,000	563
	“Net Health is a leading provider of specialized SaaS healthcare technology, empowering providers across the continuum of care, from hospital to home.” Source: company website · checked Sep 3, 2026
20	BrightreePartial evidence	Peachtree Corners, GA, United StatesHQ checked Sep 3, 2026	501-1,000	516
	“At Brightree, we believe in building innovative technology solutions and providing services to the post-acute healthcare industry that help to enhance clinical and business…” Source: company website · checked Sep 3, 2026
21	Anthelio Healthcare SolutionsIndirect evidence	Dallas, TX, United StatesHQ checked Sep 3, 2026	1,001-5,000	511
	“Anthelio is now Atos.” Source: company website · checked Sep 3, 2026
22	EMDSIndirect evidence	Austin, TX, United StatesHQ checked Sep 3, 2026	501-1,000	486
	“CompuGroup Medical is a leading provider of healthy solutions for healthy patients and healthy providers.” Source: company website · checked Sep 3, 2026
23	Vālenz HealthPartial evidence	Radnor, PA, United StatesHQ checked Sep 3, 2026	501-1,000	326
	“Vālenz Health® is the platform to simplify healthcare – the destination for employers, payers, providers, and members to reduce costs, improve quality, and elevate the healthcare…” Source: company website · checked Sep 3, 2026
24	Compugroup Medical USPartial evidence	Richardson, TX, United StatesHQ checked Sep 3, 2026	5,001-10,000	319
	“CompuGroup Medical is a global e-health provider with a comprehensive portfolio of cutting-edge IT solutions for the healthcare industry.” Source: company website · checked Sep 3, 2026
25	Ehealth TechnologiesPartial evidence	Fairport, PA, United StatesHQ checked Sep 3, 2026	501-1,000	303
	“Since 2006, eHealth Technologies has helped healthcare organizations close the time-to-treatment gap by delivering timely, organized, clinically relevant, specialty-specific…” Source: company website · checked Sep 3, 2026

Showing 25 of 1,199 healthcare middleware software companies based in the United States

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Healthcare middleware software companies based in the United States at a glance

As of Sep 3, 2026

11-50Median size (employees)

New YorkLargest hub · 30 HQs

19,910Contacts with mobile numbers

Sep 3, 2026Data refreshed

Companies by employee count

1-10

362

11-50

489

51-200

219

201-500

501-1,000

1,001-5,000

5,001-10,000

10001+

Verified emails by last verification

0–30

31–60

1,947

61–90

13,598

90–180

8,015

180+

167

How this list was built

Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among healthcare middleware software companies, so some rows will be adjacent to the category rather than pure plays. The description and evidence rating on every row are there so you can check each match yourself.

Source: The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase SmartSearch, the natural-language company search available to every RevenueBase user.
What qualifies: Companies headquartered in the United States whose own description of what they do matches “healthcare middleware software companies”. Matching reads each company's description, not its industry code or its name.
What we exclude: Companies whose own description does not clearly place them among healthcare middleware software companies, and records with no verified work email. Companies headquartered outside United States are excluded even when they keep an office there.
Match quality: In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and an evidence rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
Ranking: Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
Verification: Every listed company carries at least one verified work email, 23,727 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
Refresh: This page's figures were pulled from the company graph on September 3, 2026. Lists refresh periodically as the graph is re-checked.
Corrections: Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.

Healthcare middleware software companies by metro

Healthcare middleware software companies in New York30
Healthcare middleware software companies in San Francisco26

Frequently asked

How many healthcare middleware software companies are there based in the United States?

RevenueBase identified 1,199 healthcare middleware software companies headquartered in the United States as of September 2026, matched on each company's own description of what it does rather than its industry code.

What is the largest company on this list?

Eclinicalworks, headquartered in Pleasanton, tops this list with the largest team on record.

Which city has the most healthcare middleware software companies?

New York leads with 30 headquartered companies, followed by San Francisco (26) and Atlanta (24).

How do I get contact information for these companies?

A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 23,727 verified decision-maker contacts tracked across these 1,199 companies.

How current is this list?

The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 3, 2026.

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About this data

RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase SmartSearch, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.