Company lists · Data refreshed September 2026

Top 25 Healthcare interoperability software companies based in the United States

Name: Healthcare interoperability software companies based in the United States
Creator: RevenueBase
License: https://creativecommons.org/licenses/by/4.0/

Compiled by the RevenueBase Data Team Data refreshed Sep 3, 2026 858 companies tracked

RevenueBase identified 858 healthcare interoperability software companies headquartered in the United States as of September 2026 and tracks 48,191 professional contacts across them, including 19,620 with verified work emails and 17,983 with mobile numbers. New York is the largest hub.

This list covers healthcare interoperability software companies headquartered in the United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, how directly it supports the match, and when it was last checked. Data refreshed September 3, 2026.

Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase SmartSearch, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.

How to read this list HQ checked on every row Match evidence on every row Refreshed Sep 3, 2026 86% judged on-target in blind review

858Companies

48,191Contacts tracked

19,620Verified emails

17,983Mobile numbers

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The 25 largest healthcare interoperability software companies based in the United States

Ranked by team size

Top 25 of 858 healthcare interoperability software companies based in the United States, ranked by team size, largest first. Data refreshed Sep 3, 2026. Evidence rates how directly each company's own description names healthcare interoperability software companies: strong (names it), partial (names part of it), indirect (matched on its full profile rather than the summary shown). Click a count to unlock that company's people.
#	Company	Headquarters	Employees	Contacts
1	EclinicalworksPartial evidence	Westborough, CA, United StatesHQ checked Sep 3, 2026	5,001-10,000	5,251
	“eClinicalWorks is a privately held leader in healthcare IT, providing comprehensive Electronic Health Record (EHR) and Practice Management (PM) solutions used by more than medical…” Source: company website · checked Sep 3, 2026
2	MeditechPartial evidence	Canton, MA, United StatesHQ checked Sep 3, 2026	1,001-5,000	3,400
	“MEDITECH empowers healthcare organizations everywhere to expand their vision of what’s possible with Expanse, the world’s most intuitive and interoperable EHR.” Source: company website · checked Sep 3, 2026
3	DatavantPartial evidence	New York City, NY, United StatesHQ checked Sep 3, 2026	5,001-10,000	2,863
	“Datavant is the data collaboration platform trusted for healthcare.” Source: company website · checked Sep 3, 2026
4	NetsmartPartial evidence	Overland Park, IL, United StatesHQ checked Sep 3, 2026	1,001-5,000	2,457
	“Netsmart is an industry-leading healthcare technology organization dedicated to empowering providers to deliver value-based care to individuals and communities.” Source: company website · checked Sep 3, 2026
5	WellskyPartial evidence	Overland Park, KS, United StatesHQ checked Sep 3, 2026	1,001-5,000	2,000
	“WellSky is one of America’s largest and most innovative healthcare technology companies leading the movement for intelligent, coordinated care.” Source: company website · checked Sep 3, 2026
6	CuremdPartial evidence	New York, NY, United StatesHQ checked Sep 3, 2026	1,001-5,000	1,713
	“Join CureMD – Innovating Healthcare, Empowering People At CureMD, we are at the forefront of healthcare innovation, driven by a passion for creating a better future.” Source: company website · checked Sep 3, 2026
7	Trizetto Healthcare ProductsIndirect evidence	Teaneck, CO, United StatesHQ checked Sep 3, 2026	10001+	995
	“Cognizant (Nasdaq-100: CTSH) is one of the world's leading professional services companies, transforming clients' business, operating and technology models for the digital era.” Source: company website · checked Sep 3, 2026
8	Simplify HealthcarePartial evidence	Aurora, IL, United StatesHQ checked Sep 3, 2026	501-1,000	960
	“Healthcare technology company providing cloud-based AI-powered SaaS solutions for health insurance payers.” Source: company website · checked Sep 3, 2026
9	CPSIPartial evidence	Emanuel, AL, United StatesHQ checked Sep 3, 2026	1,001-5,000	850
	“CPSI is a leading provider of healthcare solutions and services for community hospitals, their clinics and post-acute care facilities.” Source: company website · checked Sep 3, 2026
10	EdifecsIndirect evidence	Bellevue, WA, United StatesHQ checked Sep 3, 2026	1,001-5,000	808
	“Edifecs, a Cotiviti business, provides market-leading technology to its payer and health system customers, which serve nearly 300 million people in the U.S.” Source: company website · checked Sep 3, 2026
11	SurescriptsPartial evidence	Arlington, NC, United StatesHQ checked Sep 3, 2026	501-1,000	712
	“At Surescripts, we bring healthcare together to inform and accelerate decisions, helping keep patient care on track.” Source: company website · checked Sep 3, 2026
12	Meditab Software INCPartial evidence	Sacramento, CA, United StatesHQ checked Sep 3, 2026	201-500	690
	“Empowering our clients with cutting edge technology to meet future healthcare needs today.” Source: company website · checked Sep 3, 2026
13	Mckesson Health SolutionsPartial evidence	Nashville, TN, United StatesHQ checked Sep 3, 2026	10001+	683
	“Change Healthcare is inspiring a better healthcare system.” Source: company website · checked Sep 3, 2026
14	Healthport TechnologiesIndirect evidence	Alpharetta, GA, United StatesHQ checked Sep 3, 2026	5,001-10,000	653
	“HealthPort Technologies is now CIOX Health.” Source: company website · checked Sep 3, 2026
15	Centauri Health Solutions, INCIndirect evidence	Tempe, OH, United StatesHQ checked Sep 3, 2026	1,001-5,000	609
	“Centauri Health Solutions aims to attract and retain the industry’s top talent as we continue to create and deliver the most flexible and innovative tools in the market.” Source: company website · checked Sep 3, 2026
16	EllkayPartial evidence	Elmwood Park, NJ, United StatesHQ checked Sep 3, 2026	501-1,000	577
	“ELLKAY is a trusted enterprise data management partner, driving innovation and connectivity across the healthcare ecosystem.” Source: company website · checked Sep 3, 2026
17	VerismaPartial evidence	Alpharetta, CO, United StatesHQ checked Sep 3, 2026	1,001-5,000	546
	“Verisma, trusted by clients across 50 states, is redefining how healthcare organizations manage and use health data – ensuring it’s trusted, secure and actionable for real-time…” Source: company website · checked Sep 3, 2026
18	Smart Data SolutionsPartial evidence	Eagan, MN, United StatesHQ checked Sep 3, 2026	501-1,000	446
	“Smart Data Solutions is a healthcare technology company helping health plans, healthcare payers, and third-party administrators (TPAs) automate complex operational workflows…” Source: company website · checked Sep 3, 2026
19	Compugroup Medical USPartial evidence	Richardson, TX, United StatesHQ checked Sep 3, 2026	5,001-10,000	319
	“CompuGroup Medical is a global e-health provider with a comprehensive portfolio of cutting-edge IT solutions for the healthcare industry.” Source: company website · checked Sep 3, 2026
20	RhapsodyStrong evidence	Boston, MA, United StatesHQ checked Sep 3, 2026	201-500	313
	“Rhapsody provides healthcare organizations with infrastructure for agent-ready interoperability so you can connect systems, reduce integration burden, and prepare your data for…” Source: company website · checked Sep 3, 2026
21	Ehealth TechnologiesPartial evidence	Fairport, PA, United StatesHQ checked Sep 3, 2026	501-1,000	303
	“Since 2006, eHealth Technologies has helped healthcare organizations close the time-to-treatment gap by delivering timely, organized, clinically relevant, specialty-specific…” Source: company website · checked Sep 3, 2026
22	Abacus InsightsPartial evidence	Boston, MA, United StatesHQ checked Sep 3, 2026	201-500	289
	“Abacus Insights is a healthcare technology leader with the only data usability platform and solutions built specifically for U.S.” Source: company website · checked Sep 3, 2026
23	314e CorporationPartial evidence	Dublin, CA, United StatesHQ checked Sep 3, 2026	501-1,000	276
	“314e is a Best in KLAS Healthcare IT Products and Solutions company, serving 250+ Providers, Payers, and Life Sciences companies.” Source: company website · checked Sep 3, 2026
24	DAS HealthPartial evidence	Tampa, TX, United StatesHQ checked Sep 3, 2026	201-500	273
	“DAS Health delivers the highest value Health IT and Business Solutions for healthcare organizations all over the country.” Source: company website · checked Sep 3, 2026
25	Regenstrief Institute, INCIndirect evidence	Indianapolis, IN, United StatesHQ checked Sep 3, 2026	201-500	233
	“Regenstrief Institute, Inc, an international leader in electronic medical records and health care data integration, is a medical research and development organization focused on…” Source: company website · checked Sep 3, 2026

Showing 25 of 858 healthcare interoperability software companies based in the United States

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Healthcare interoperability software companies based in the United States at a glance

As of Sep 3, 2026

11-50Median size (employees)

New YorkLargest hub · 28 HQs

17,983Contacts with mobile numbers

Sep 3, 2026Data refreshed

Companies by employee count

1-10

277

11-50

362

51-200

151

201-500

501-1,000

1,001-5,000

5,001-10,000

10001+

Verified emails by last verification

0–30

31–60

1,636

61–90

11,084

90–180

6,739

180+

161

How this list was built

Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among healthcare interoperability software companies, so some rows will be adjacent to the category rather than pure plays. The description and evidence rating on every row are there so you can check each match yourself.

Source: The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase SmartSearch, the natural-language company search available to every RevenueBase user.
What qualifies: Companies headquartered in the United States whose own description of what they do matches “healthcare interoperability software companies”. Matching reads each company's description, not its industry code or its name.
What we exclude: Companies whose own description does not clearly place them among healthcare interoperability software companies, and records with no verified work email. Companies headquartered outside United States are excluded even when they keep an office there.
Match quality: In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and an evidence rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
Ranking: Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
Verification: Every listed company carries at least one verified work email, 19,620 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
Refresh: This page's figures were pulled from the company graph on September 3, 2026. Lists refresh periodically as the graph is re-checked.
Corrections: Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.

Healthcare interoperability software companies by metro

Healthcare interoperability software companies in New York28

Frequently asked

How many healthcare interoperability software companies are there based in the United States?

RevenueBase identified 858 healthcare interoperability software companies headquartered in the United States as of September 2026, matched on each company's own description of what it does rather than its industry code.

What is the largest company on this list?

Eclinicalworks, headquartered in Pleasanton, tops this list with the largest team on record.

Which city has the most healthcare interoperability software companies?

New York leads with 28 headquartered companies, followed by San Francisco (15) and Austin (14).

How do I get contact information for these companies?

A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 19,620 verified decision-maker contacts tracked across these 858 companies.

How current is this list?

The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 3, 2026.

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About this data

RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase SmartSearch, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.