Company lists · Data refreshed September 2026

Top 25 Healthcare interoperability companies based in the United States

Name: Healthcare interoperability companies based in the United States
Creator: RevenueBase
License: https://creativecommons.org/licenses/by/4.0/

Compiled by the RevenueBase Data Team Data refreshed Sep 16, 2026 878 companies tracked

RevenueBase identified 878 healthcare interoperability companies headquartered in the United States as of September 2026 and tracks 46,111 professional contacts across them, including 20,526 with verified work emails. New York is the largest hub.

This list covers healthcare interoperability companies headquartered in the United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, its RevenueBase Smart Search rating, and when it was last checked. Data refreshed September 16, 2026.

Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase Smart Search, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.

How to read this list HQ checked on every row RevenueBase Smart Search rating on every row Refreshed Sep 16, 2026 86% judged on-target in blind review

878Companies

46,111Contacts tracked

20,526Verified emails

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The 25 largest healthcare interoperability companies based in the United States

Ranked by team size

Top 25 of 878 healthcare interoperability companies based in the United States, ranked by team size, largest first. Data refreshed Sep 16, 2026. RevenueBase Smart Search rates how each company's information relates to healthcare interoperability companies: strong evidence (its own description names it), partial (names part of it), indirect (matched on the rest of its profile rather than the description shown). Click a contact count to view that company's people.
#	Company	RevenueBase Smart Search	Headquarters	Employees	Contacts
1	Premier INC	Indirect evidence	Charlotte, NC, United StatesHQ checked Sep 16, 2026	1,001-5,000	3,380 contacts →
	Indirect evidence “Premier, Inc.” Source: RevenueBase Database · checked Sep 16, 2026
2	Datavant	Partial evidence	New York City, NY, United StatesHQ checked Sep 16, 2026	5,001-10,000	2,839 contacts →
	Partial evidence “Datavant is the data collaboration platform trusted for healthcare.” Source: RevenueBase Database · checked Sep 16, 2026
3	ZELIS	Partial evidence	Boston, MA, United StatesHQ checked Sep 16, 2026	1,001-5,000	2,484 contacts →
	Partial evidence “Zelis is modernizing the healthcare financial experience by providing a connected platform that bridges the gaps and aligns interests across payers, providers, and healthcare…” Source: RevenueBase Database · checked Sep 16, 2026
4	Netsmart	Partial evidence	Overland Park, KS, United StatesHQ checked Sep 16, 2026	1,001-5,000	2,438 contacts →
	Partial evidence “Netsmart is an industry-leading healthcare technology organization dedicated to empowering providers to deliver value-based care to individuals and communities.” Source: RevenueBase Database · checked Sep 16, 2026
5	Wellsky	Partial evidence	Overland Park, KS, United StatesHQ checked Sep 16, 2026	1,001-5,000	2,017 contacts →
	Partial evidence “WellSky is one of America’s largest and most innovative healthcare technology companies leading the movement for intelligent, coordinated care.” Source: RevenueBase Database · checked Sep 16, 2026
6	Symplr	Indirect evidence	Houston, TX, United StatesHQ checked Sep 16, 2026	1,001-5,000	1,820 contacts →
	Indirect evidence “Simplify Operations.” Source: RevenueBase Database · checked Sep 16, 2026
7	Greenway Health	Partial evidence	Tampa, FL, United StatesHQ checked Sep 16, 2026	1,001-5,000	1,778 contacts →
	Partial evidence “Greenway Health is a leading health information technology company delivering enterprise-wide healthcare platform solutions that support clinical, financial, and patient…” Source: RevenueBase Database · checked Sep 16, 2026
8	Mckesson Health IT	Partial evidence	Nashville, TN, United StatesHQ checked Sep 16, 2026	10001+	1,310 contacts →
	Partial evidence “Change Healthcare is inspiring a better healthcare system.” Source: RevenueBase Database · checked Sep 16, 2026
9	Sharecare	Partial evidence	Atlanta, GA, United StatesHQ checked Sep 16, 2026	1,001-5,000	1,196 contacts →
	Partial evidence “Sharecare is a digital healthcare company that delivers software and tech-enabled services to stakeholders across the healthcare ecosystem to help improve care quality, drive…” Source: RevenueBase Database · checked Sep 16, 2026
10	Simplify Healthcare	Partial evidence	Aurora, IL, United StatesHQ checked Sep 16, 2026	501-1,000	945 contacts →
	Partial evidence “Healthcare technology company providing cloud-based AI-powered SaaS solutions for health insurance payers.” Source: RevenueBase Database · checked Sep 16, 2026
11	Edifecs	Indirect evidence	Bellevue, WA, United StatesHQ checked Sep 16, 2026	1,001-5,000	796 contacts →
	Indirect evidence “Edifecs, a Cotiviti business, provides market-leading technology to its payer and health system customers, which serve nearly 300 million people in the U.S.” Source: RevenueBase Database · checked Sep 16, 2026
12	Surescripts	Partial evidence	Arlington, VA, United StatesHQ checked Sep 16, 2026	501-1,000	706 contacts →
	Partial evidence “At Surescripts, we bring healthcare together to inform and accelerate decisions, helping keep patient care on track.” Source: RevenueBase Database · checked Sep 16, 2026
13	The Craneware Group	Partial evidence	Deerfield Beach, FL, United StatesHQ checked Sep 16, 2026	501-1,000	704 contacts →
	Partial evidence “For over 25 years, The Craneware Group has led healthcare financial and operational transformation with innovative technologies that drive measurable results.” Source: RevenueBase Database · checked Sep 16, 2026
14	Healthport Technologies	Indirect evidence	Alpharetta, GA, United StatesHQ checked Sep 16, 2026	5,001-10,000	651 contacts →
	Indirect evidence “HealthPort Technologies is now CIOX Health.” Source: RevenueBase Database · checked Sep 16, 2026
15	Ellkay	Partial evidence	Elmwood Park, NJ, United StatesHQ checked Sep 16, 2026	501-1,000	585 contacts →
	Partial evidence “ELLKAY is a trusted enterprise data management partner, driving innovation and connectivity across the healthcare ecosystem.” Source: RevenueBase Database · checked Sep 16, 2026
16	Immucor, INC	Indirect evidence	Norcross, GA, United StatesHQ checked Sep 16, 2026	1,001-5,000	547 contacts →
	Indirect evidence “We are excited to be ONE with Werfen and contribute to powering patient care.” Source: RevenueBase Database · checked Sep 16, 2026
17	Verisma	Partial evidence	Alpharetta, GA, United StatesHQ checked Sep 16, 2026	1,001-5,000	546 contacts →
	Partial evidence “Verisma, trusted by clients across 50 states, is redefining how healthcare organizations manage and use health data – ensuring it’s trusted, secure and actionable for real-time…” Source: RevenueBase Database · checked Sep 16, 2026
18	Smart Data Solutions	Partial evidence	Eagan, MN, United StatesHQ checked Sep 16, 2026	501-1,000	448 contacts →
	Partial evidence “Smart Data Solutions is a healthcare technology company helping health plans, healthcare payers, and third-party administrators (TPAs) automate complex operational workflows…” Source: RevenueBase Database · checked Sep 16, 2026
19	Thinkitive INC	Indirect evidence	Dover, DE, United StatesHQ checked Sep 16, 2026	201-500	415 contacts →
	Indirect evidence “Thinkitive is a technology and solution provider of the next-gen business team up with clients worldwide.” Source: RevenueBase Database · checked Sep 16, 2026
20	H1	Indirect evidence	New York, NY, United StatesHQ checked Sep 16, 2026	201-500	406 contacts →
	Indirect evidence “H1 is on a mission to connect the world with the right doctors.” Source: RevenueBase Database · checked Sep 16, 2026
21	Vālenz Health	Partial evidence	Radnor, PA, United StatesHQ checked Sep 16, 2026	501-1,000	335 contacts →
	Partial evidence “Vālenz Health® is the platform to simplify healthcare, the destination for employers, brokers, payers, and providers to reduce costs, improve quality, and elevate the healthcare…” Source: RevenueBase Database · checked Sep 16, 2026
22	Compugroup Medical US	Partial evidence	Richardson, TX, United StatesHQ checked Sep 16, 2026	5,001-10,000	320 contacts →
	Partial evidence “CompuGroup Medical is a global e-health provider with a comprehensive portfolio of cutting-edge IT solutions for the healthcare industry.” Source: RevenueBase Database · checked Sep 16, 2026
23	Rhapsody	Strong evidence	Boston, MA, United StatesHQ checked Sep 16, 2026	201-500	314 contacts →
	Strong evidence “Rhapsody provides healthcare organizations with infrastructure for agent-ready interoperability so you can connect systems, reduce integration burden, and prepare your data for…” Source: RevenueBase Database · checked Sep 16, 2026
24	Ehealth Technologies	Partial evidence	Fairport, NY, United StatesHQ checked Sep 16, 2026	501-1,000	306 contacts →
	Partial evidence “Since 2006, eHealth Technologies has helped healthcare organizations close the time-to-treatment gap by delivering timely, organized, clinically relevant, specialty-specific…” Source: RevenueBase Database · checked Sep 16, 2026
25	Tigerconnect	Partial evidence	El Segundo, CA, United StatesHQ checked Sep 16, 2026	201-500	299 contacts →
	Partial evidence “Healthcare communication has become fragmented across systems, devices, and departments, forcing clinicians to act as the “middleware” that manually routes information when…” Source: RevenueBase Database · checked Sep 16, 2026

RevenueBase Smart Search

RevenueBase Smart Search assesses information from a company’s LinkedIn profile, information supplied directly by the company, its website, and other publicly available sources. It uses that information to rate how closely the company relates to this list’s category: healthcare interoperability companies. Every row carries its rating and the description the rating was read from, so each one can be checked rather than taken on trust.

Strong evidence: The company's own public description of its business names healthcare interoperability companies.
Partial evidence: Its own public description names part of healthcare interoperability companies, so it works in or next to the category without describing itself that way.
Indirect evidence: The description shown does not name healthcare interoperability companies. The match rests on the rest of the company's public profile rather than the one sentence quoted here, so this is the rating to check first.

RevenueBase Smart Search is how these lists are built: RevenueBase's data engine and AI assemble the companies that match a category defined in a user's own words, so a list can be about what companies actually do rather than about whichever industry code they were filed under.

Showing 25 of 878 healthcare interoperability companies based in the United States

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Healthcare interoperability companies based in the United States at a glance

As of Sep 16, 2026

44.5%Verified-email coverage

52.5Average contacts per company

11-50Median size (employees)

3.3%Largest-city concentration · New York

Sep 16, 2026Page data refreshed

Companies by employee count

1-10

290

11-50

353

51-200

158

201-500

501-1,000

1,001-5,000

5,001-10,000

10001+

Email recency for this list is measured worldwide rather than for United States, so it is reported there. Company counts and contact totals on this page are exact for United States, over 878 companies.

How this list was built

Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among healthcare interoperability companies, so some rows will be adjacent to the category rather than pure plays. The description and RevenueBase Smart Search rating on every row are there so you can check each match yourself.

Source: The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase Smart Search, the natural-language company search available to every RevenueBase user.
What qualifies: Companies headquartered in the United States whose own description of what they do matches “healthcare interoperability companies”. Matching reads each company's description, not its industry code or its name.
RevenueBase Smart Search: RevenueBase Smart Search is how this list is assembled and how each row is rated. RevenueBase's data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to a category defined in a user's own words. Each row is rated strong evidence (its own description names healthcare interoperability companies), partial evidence (it names part of the category) or indirect evidence (the description shown names none of it and the match rests on the rest of the company's profile). The description supporting each rating is quoted on the row.
What we exclude: Companies whose own description does not clearly place them among healthcare interoperability companies, and records with no verified work email. Companies headquartered outside United States are excluded even when they keep an office there.
Match quality: In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and its RevenueBase Smart Search rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
Ranking: Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
Verification: Every listed company carries at least one verified work email, 20,526 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
Refresh: This page's figures were pulled from the company graph on September 16, 2026. Lists refresh periodically as the graph is re-checked.
Corrections: Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.

Healthcare interoperability companies by metro

Healthcare interoperability companies in New York29

Frequently asked

What is RevenueBase Smart Search?

RevenueBase Smart Search is how RevenueBase decides which companies belong on this list and how strongly each one fits. Its data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to the category the list is about. Each row is rated strong evidence when the company's own description names healthcare interoperability companies, partial evidence when it names part of the category, and indirect evidence when the description shown names none of it and the match rests on the rest of the company's profile.

How many healthcare interoperability companies are there based in the United States?

RevenueBase identified 878 healthcare interoperability companies headquartered in the United States as of September 2026, matched on each company's own description of what it does rather than its industry code.

What is the largest company on this list?

Premier INC, headquartered in Charlotte, tops this list with the largest team on record.

Which city has the most healthcare interoperability companies?

New York leads with 29 headquartered companies, followed by Chicago (19) and Atlanta (16).

How do I get contact information for these companies?

A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 20,526 verified decision-maker contacts tracked across these 878 companies.

How current is this list?

The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 16, 2026.

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About this data

RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase Smart Search, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.