Company lists · Data refreshed September 2026

Top 25 Digital therapy software companies based in the United States

Name: Digital therapy software companies based in the United States
Creator: RevenueBase
License: https://creativecommons.org/licenses/by/4.0/

Compiled by the RevenueBase Data Team Data refreshed Sep 28, 2026 274 companies tracked

RevenueBase identified 274 digital therapy software companies headquartered in the United States as of September 2026 and tracks 5,827 professional contacts across them, including 1,877 with verified work emails. New York is the largest hub.

This list covers digital therapy software companies headquartered in the United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, its RevenueBase Smart Search rating, and when it was last checked. Data refreshed September 28, 2026.

Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase Smart Search, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.

How to read this list HQ checked on every row RevenueBase Smart Search rating on every row Refreshed Sep 28, 2026 86% judged on-target in blind review

274Companies

5,827Contacts tracked

1,877Verified emails

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The 25 largest digital therapy software companies based in the United States

Ranked by team size

Top 25 of 274 digital therapy software companies based in the United States, ranked by team size, largest first. Data refreshed Sep 28, 2026. RevenueBase Smart Search rates how each company's information relates to digital therapy software companies: strong evidence (its own description names it), partial (names part of it), indirect (matched on the rest of its profile rather than the description shown). Click a contact count to view that company's people.
#	Company	RevenueBase Smart Search	Headquarters	Employees	Contacts
1	Talkspace	Partial evidence	New York, NY, United StatesHQ checked Sep 28, 2026	201-500	1,064 contacts →
	Partial evidence “A leading provider of virtual mental health care, Talkspace provides convenient access to high-quality, evidence-based therapy, psychiatry, and self-guided support.” Source: RevenueBase Database · checked Sep 28, 2026
2	TWO Chairs	Indirect evidence	San Francisco, CA, United StatesHQ checked Sep 28, 2026	501-1,000	586 contacts →
	Indirect evidence “We’re building a world where everyone has access to exceptional mental health care.” Source: RevenueBase Database · checked Sep 28, 2026
3	Telemynd	Indirect evidence	Maynard, MA, United StatesHQ checked Sep 28, 2026	51-200	280 contacts →
	Indirect evidence “Telemynd combines the power of personalized technology with the expertise of trained, supported professionals to deliver comprehensive mental health services that increase care…” Source: RevenueBase Database · checked Sep 28, 2026
4	Resilience LAB	Indirect evidence	New York, NY, United StatesHQ checked Sep 28, 2026	201-500	212 contacts →
	Indirect evidence “Resilience Lab is modernizing how clinicians work together to provide mental health care that’s high-quality, personalized, and accessible.” Source: RevenueBase Database · checked Sep 28, 2026
5	Click Therapeutics, INC	Strong evidence	NY, United StatesHQ checked Sep 28, 2026	51-200	158 contacts →
	Strong evidence “Click Therapeutics, Inc, develops, validates, and commercializes software as prescription medical treatments for people with unmet medical needs.” Source: RevenueBase Database · checked Sep 28, 2026
6	Affect	Partial evidence	Remote, United StatesHQ checked Sep 28, 2026	51-200	138 contacts →
	Partial evidence “Affect is a nationally-scaled, online provider of therapy and psychiatric services for mental health and substance use disorders.” Source: RevenueBase Database · checked Sep 28, 2026
7	Meru Health	Indirect evidence	San Mateo, CA, United StatesHQ checked Sep 28, 2026	51-200	131 contacts →
	Indirect evidence “At Meru Health, our mission is deeply personal.” Source: RevenueBase Database · checked Sep 28, 2026
8	Linus Health	Partial evidence	Boston, MA, United StatesHQ checked Sep 28, 2026	51-200	126 contacts →
	Partial evidence “Linus Health is a Boston-based digital health company focused on transforming brain health for people across the world.” Source: RevenueBase Database · checked Sep 28, 2026
9	Little Otter	Partial evidence	San Francisco, CA, United StatesHQ checked Sep 28, 2026	11-50	124 contacts →
	Partial evidence “Little Otter is a digital mental health company that offers holistic, evidence-backed care for children 0-18 and their families.” Source: RevenueBase Database · checked Sep 28, 2026
10	Mantra Health	Strong evidence	New York, NY, United StatesHQ checked Sep 28, 2026	51-200	119 contacts →
	Strong evidence “Mantra Health is a digital mental health clinic on a mission to improve young peoples' mental healthcare access through clinical services, software, and design.” Source: RevenueBase Database · checked Sep 28, 2026
11	Sohomd, Pllc	Indirect evidence	New York, NY, United StatesHQ checked Sep 28, 2026	51-200	105 contacts →
	Indirect evidence “SohoMD is a telepsychiatry and teletherapy organization, using technology to efficiently deliver high-quality psychiatric care to patients.” Source: RevenueBase Database · checked Sep 28, 2026
12	Aura Health	Indirect evidence	San Francisco, CA, United StatesHQ checked Sep 28, 2026	11-50	105 contacts →
	Indirect evidence “Aura is an all-in-one app for mental wellbeing & sleep.” Source: RevenueBase Database · checked Sep 28, 2026
13	BIG Health	Indirect evidence	San Francisco, CA, United StatesHQ checked Sep 28, 2026	51-200	102 contacts →
	Indirect evidence “We make it easy to access effective mental health care anywhere, anytime.” Source: RevenueBase Database · checked Sep 28, 2026
14	Kaia Health	Partial evidence	New York, NY, United StatesHQ checked Sep 28, 2026	51-200	92 contacts →
	Partial evidence “Kaia is a leading digital MSK company and was acquired by Sword Health in January 2026.” Source: RevenueBase Database · checked Sep 28, 2026
15	Silvercloud By Amwell	Partial evidence	Boston, MA, United StatesHQ checked Sep 28, 2026	501-1,000	67 contacts →
	Partial evidence “SilverCloud® by Amwell® (NYSE: AMWL) is a leading digital mental health platform, enabling providers, health plans and employers to deliver clinically validated digital…” Source: RevenueBase Database · checked Sep 28, 2026
16	Health Care Systems, INC	Partial evidence	Montgomery, AL, United StatesHQ checked Sep 28, 2026	11-50	67 contacts →
	Partial evidence “HCS has been building healthcare software since 1984.” Source: RevenueBase Database · checked Sep 28, 2026
17	Joyous	Partial evidence	Silicon Valley, CA, United StatesHQ checked Sep 28, 2026	11-50	57 contacts →
	Partial evidence “Joyous PBC is an AI powered digital platform that enables patients to take charge of their mental health.” Source: RevenueBase Database · checked Sep 28, 2026
18	Reachlink	Indirect evidence	Boca Raton, FL, United StatesHQ checked Sep 28, 2026	51-200	57 contacts →
	Indirect evidence “ReachLink is redefining mental health care through innovation, accessibility, and impact.” Source: RevenueBase Database · checked Sep 28, 2026
19	OWL Practice Suite	Indirect evidence	Atlanta, GA, United StatesHQ checked Sep 28, 2026	51-200	55 contacts →
	Indirect evidence “We make it easier to access and deliver care, allowing mental health professionals to treat more people and individuals to focus on leading happier, more fulfilling lives.” Source: RevenueBase Database · checked Sep 28, 2026
20	Curajoy	Indirect evidence	Carlsbad, CA, United StatesHQ checked Sep 28, 2026	51-200	46 contacts →
	Indirect evidence “How we feel about ourselves, interact with others, and overcome obstacles in life makes an enormous difference in our ability to be happy and to succeed.” Source: RevenueBase Database · checked Sep 28, 2026
21	Crediblemind	Indirect evidence	Sausalito, CA, United StatesHQ checked Sep 28, 2026	11-50	39 contacts →
	Indirect evidence “Leading health plans, program providers, and over 100 communities across the U.S, rely on CredibleMind to empower member mental health anytime, anywhere.” Source: RevenueBase Database · checked Sep 28, 2026
22	Calmerry	Partial evidence	Cody, WY, United StatesHQ checked Sep 28, 2026	51-200	37 contacts →
	Partial evidence “Calmerry is a trusted online therapy platform founded in 2020 as a response to the growing need for mental health support during lockdown.” Source: RevenueBase Database · checked Sep 28, 2026
23	Prevail Health	Indirect evidence	Chicago, IL, United StatesHQ checked Sep 28, 2026	11-50	35 contacts →
	Indirect evidence “Prevail Health is a leader in technology-based behavioral health and resilience building for a wide range of challenges from depression to PTSD to substance abuse.” Source: RevenueBase Database · checked Sep 28, 2026
24	Graymatters Health	Partial evidence	New York, NY, United StatesHQ checked Sep 28, 2026	11-50	34 contacts →
	Partial evidence “GrayMatters Health (GMH) is a health technology company developing and marketing an interventional psychiatry suite powered by digital fMRI-Informed biomarkers.” Source: RevenueBase Database · checked Sep 28, 2026
25	Revive Therapeutic Services	Partial evidence	Providence, RI, United StatesHQ checked Sep 28, 2026	51-200	34 contacts →
	Partial evidence “Revive Therapeutic Services is a licensed behavioral health agency serving Rhode Island and Massachusetts, built on the belief that quality psychiatric and therapeutic care should…” Source: RevenueBase Database · checked Sep 28, 2026

RevenueBase Smart Search

RevenueBase Smart Search assesses information from a company’s LinkedIn profile, information supplied directly by the company, its website, and other publicly available sources. It uses that information to rate how closely the company relates to this list’s category: digital therapy software companies. Every row carries its rating and the description the rating was read from, so each one can be checked rather than taken on trust.

Strong evidence: The company's own public description of its business names digital therapy software companies.
Partial evidence: Its own public description names part of digital therapy software companies, so it works in or next to the category without describing itself that way.
Indirect evidence: The description shown does not name digital therapy software companies. The match rests on the rest of the company's public profile rather than the one sentence quoted here, so this is the rating to check first.

RevenueBase Smart Search is how these lists are built: RevenueBase's data engine and AI assemble the companies that match a category defined in a user's own words, so a list can be about what companies actually do rather than about whichever industry code they were filed under.

Showing 25 of 274 digital therapy software companies based in the United States

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Digital therapy software companies based in the United States at a glance

As of Sep 28, 2026

32.2%Verified-email coverage

21.3Average contacts per company

1-10Median size (employees)

12.8%Largest-city concentration · New York

Sep 28, 2026Page data refreshed

Companies by employee count

1-10

152

11-50

51-200

201-500

501-1,000

10001+

Email recency for this list is measured worldwide rather than for United States, so it is reported there. Company counts and contact totals on this page are exact for United States, over 274 companies.

How this list was built

Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among digital therapy software companies, so some rows will be adjacent to the category rather than pure plays. The description and RevenueBase Smart Search rating on every row are there so you can check each match yourself.

Source: The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase Smart Search, the natural-language company search available to every RevenueBase user.
What qualifies: Companies headquartered in the United States whose own description of what they do matches “digital therapy software companies”. Matching reads each company's description, not its industry code or its name.
RevenueBase Smart Search: RevenueBase Smart Search is how this list is assembled and how each row is rated. RevenueBase's data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to a category defined in a user's own words. Each row is rated strong evidence (its own description names digital therapy software companies), partial evidence (it names part of the category) or indirect evidence (the description shown names none of it and the match rests on the rest of the company's profile). The description supporting each rating is quoted on the row.
What we exclude: Companies whose own description does not clearly place them among digital therapy software companies, and records with no verified work email. Companies headquartered outside United States are excluded even when they keep an office there.
Match quality: In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and its RevenueBase Smart Search rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
Ranking: Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
Verification: Every listed company carries at least one verified work email, 1,877 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
Refresh: This page's figures were pulled from the company graph on September 28, 2026. Lists refresh periodically as the graph is re-checked.
Corrections: Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.

Digital therapy software companies by metro

Frequently asked

What is RevenueBase Smart Search?

RevenueBase Smart Search is how RevenueBase decides which companies belong on this list and how strongly each one fits. Its data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to the category the list is about. Each row is rated strong evidence when the company's own description names digital therapy software companies, partial evidence when it names part of the category, and indirect evidence when the description shown names none of it and the match rests on the rest of the company's profile.

How many digital therapy software companies are there based in the United States?

RevenueBase identified 274 digital therapy software companies headquartered in the United States as of September 2026, matched on each company's own description of what it does rather than its industry code.

What is the largest company on this list?

Talkspace, headquartered in New York, tops this list with the largest team on record.

Which city has the most digital therapy software companies?

New York leads with 35 headquartered companies, followed by San Francisco (33) and Boston (9).

How do I get contact information for these companies?

A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 1,877 verified decision-maker contacts tracked across these 274 companies.

How current is this list?

The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 28, 2026.

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About this data

RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase Smart Search, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.