Company lists · Data refreshed September 2026
Top 25 Defi venture capital firms based in San Francisco, United States
RevenueBase identified 97 defi venture capital firms headquartered in San Francisco, United States as of September 2026 and tracks 1,967 professional contacts across them, including 477 with verified work emails. Across the United States, San Francisco is the largest hub for this category.
This list covers defi venture capital firms headquartered in San Francisco, United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, its RevenueBase Smart Search rating, and when it was last checked. Data refreshed September 28, 2026.
Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase Smart Search, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.
The 25 largest defi venture capital firms based in San Francisco, United States
Ranked by team size| # | Company | Contacts | |||
|---|---|---|---|---|---|
| 1 | 711 contacts → | ||||
Strong evidence “Hustle Fund is a venture capital firm investing in hilariously-early pre-seed founders.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 2 | 130 contacts → | ||||
Indirect evidence “Paradigm is a frontier technology investment firm led by Matt Huang and Alana Palmedo that builds and invests across crypto, AI, robotics, and other new frontiers from the…” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 3 | 105 contacts → | ||||
Strong evidence “Human Capital is a multi-stage venture capital firm.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 4 | 94 contacts → | ||||
Partial evidence “Blockchain Capital was founded in 2013 with the mission of helping entrepreneurs build world-class companies and projects based on blockchain technology – providing founders with…” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 5 | 81 contacts → | ||||
Strong evidence “SemperVirens is a San Francisco based venture capital firm investing in AI-native companies transforming the largest and most complex service markets in the economy: healthcare…” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 6 | 62 contacts → | ||||
Strong evidence “Founded in Industry Ventures has pioneered flexible capital solutions over the past 25+ years across the life cycle of venture – from seed- and early-stage investing to late-stage…” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 7 | 47 contacts → | ||||
Strong evidence “Crosslink, founded in 1989, is a premier early-stage venture capital firm with over $4.2B in assets.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 8 | 39 contacts → | ||||
Indirect evidence “We invest in idea-stage and pre-seed fintechs globally, anchoring on founder-market fit.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 9 | 36 contacts → | ||||
Partial evidence “Framework Ventures is a leading VC firm with a track record of partnering with winning founders.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 10 | 36 contacts → | ||||
Strong evidence “Robust is an early-stage, industry-agnostic venture capital firm that invests globally.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 11 | 32 contacts → | ||||
Strong evidence “We set the standard in seed stage venture capital, backing founders with grit, audacity, and a spark of rebellion.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 12 | 29 contacts → | ||||
Indirect evidence “Builders believes it takes more than great technology to fix an antiquated industry.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 13 | 28 contacts → | ||||
Partial evidence “Transpose Platform is redefining early-stage investing by backing the next generation of venture structures, accelerators, and the breakout companies they nurture.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 14 | 24 contacts → | ||||
Indirect evidence “Orange Collective invests at the center of two explosive forces: AI and YC.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 15 | 20 contacts → | ||||
Partial evidence “Shield Capital is a team of veteran investors, founders and national security leaders who are helping founders build frontier solutions in cybersecurity, artificial intelligence…” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 16 | 20 contacts → | ||||
Indirect evidence “At LBank Labs, we thrive on the power of connections and believe in fostering strong relationships within the industry.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 17 | 19 contacts → | ||||
Partial evidence “Mana Ventures is a San Francisco based VC firm that invests in early stage software and deep tech companies.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 18 | 15 contacts → | ||||
Indirect evidence “Alsop Louie Partners is a team of seasoned investors who are entrepreneurs and executives with distinctive reputations.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 19 | 14 contacts → | ||||
Partial evidence “Akkadian is a venture firm built on redefining strategic liquidity through inventive structures and trusted access.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 20 | 13 contacts → | ||||
Partial evidence “Amity Ventures is a people-focused firm that supports founders of technology companies in building category-defining businesses.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 21 | 11 contacts → | ||||
Strong evidence “Momentum 6 is a venture capital, venture builder, research, and marketing firm creating the leading blockchain companies of the future.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 22 | 10 contacts → | ||||
Strong evidence “Advance Venture Partners (“AVP”) is an evergreen venture capital firm designed to make concentrated, long-duration investments in disruptive technology and technology-enabled…” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 23 | 10 contacts → | ||||
Indirect evidence “We invest in near frontier tech that will change the world.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 24 | 10 contacts → | ||||
Strong evidence “gCC is a boutique early-stage venture capital firm based in Silicon Valley.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
| 25 | 9 contacts → | ||||
Indirect evidence “At R136, our mission is to propel creative entrepreneurs to a faster growth trajectory.” Source: RevenueBase Database · checked Sep 28, 2026Thanks. The Data Team will review it. | |||||
RevenueBase Smart Search
RevenueBase Smart Search assesses information from a company’s LinkedIn profile, information supplied directly by the company, its website, and other publicly available sources. It uses that information to rate how closely the company relates to this list’s category: defi venture capital firms. Every row carries its rating and the description the rating was read from, so each one can be checked rather than taken on trust.
- Strong evidence
- The company's own public description of its business names defi venture capital firms.
- Partial evidence
- Its own public description names part of defi venture capital firms, so it works in or next to the category without describing itself that way.
- Indirect evidence
- The description shown does not name defi venture capital firms. The match rests on the rest of the company's public profile rather than the one sentence quoted here, so this is the rating to check first.
RevenueBase Smart Search is how these lists are built: RevenueBase's data engine and AI assemble the companies that match a category defined in a user's own words, so a list can be about what companies actually do rather than about whichever industry code they were filed under.
Showing 25 of 97 defi venture capital firms based in San Francisco, United States
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Defi venture capital firms based in San Francisco, United States at a glance
As of Sep 28, 2026Companies by employee count
Email recency for this list is measured across the whole United States list rather than for San Francisco, so it is reported there. Company counts and contact totals on this page are exact for San Francisco, over 97 companies.
How this list was built
Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among defi venture capital firms, so some rows will be adjacent to the category rather than pure plays. The description and RevenueBase Smart Search rating on every row are there so you can check each match yourself.
- Source
- The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase Smart Search, the natural-language company search available to every RevenueBase user.
- What qualifies
- Companies headquartered in San Francisco, United States whose own description of what they do matches “defi venture capital firms”. Matching reads each company's description, not its industry code or its name.
- RevenueBase Smart Search
- RevenueBase Smart Search is how this list is assembled and how each row is rated. RevenueBase's data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to a category defined in a user's own words. Each row is rated strong evidence (its own description names defi venture capital firms), partial evidence (it names part of the category) or indirect evidence (the description shown names none of it and the match rests on the rest of the company's profile). The description supporting each rating is quoted on the row.
- What we exclude
- Companies whose own description does not clearly place them among defi venture capital firms, and records with no verified work email. Companies headquartered outside San Francisco are excluded even when they keep an office there.
- Match quality
- In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and its RevenueBase Smart Search rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
- Ranking
- Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
- Verification
- Every listed company carries at least one verified work email, 477 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
- Refresh
- This page's figures were pulled from the company graph on September 28, 2026. Lists refresh periodically as the graph is re-checked.
- Corrections
- Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.
Defi venture capital firms by metro in the United States
Frequently asked
What is RevenueBase Smart Search?
RevenueBase Smart Search is how RevenueBase decides which companies belong on this list and how strongly each one fits. Its data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to the category the list is about. Each row is rated strong evidence when the company's own description names defi venture capital firms, partial evidence when it names part of the category, and indirect evidence when the description shown names none of it and the match rests on the rest of the company's profile.
How many defi venture capital firms are there based in San Francisco, United States?
RevenueBase identified 97 defi venture capital firms headquartered in San Francisco, United States as of September 2026, matched on each company's own description of what it does rather than its industry code.
What is the largest company on this list?
Hustle Fund, headquartered in San Francisco, tops this list with the largest team on record.
Which city in the United States has the most defi venture capital firms?
San Francisco leads the United States with 97 headquartered companies, followed by New York (86) and Los Angeles (26).
How do I get contact information for these companies?
A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 477 verified decision-maker contacts tracked across these 97 companies.
How current is this list?
The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 28, 2026.
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Defi venture capital firms by geography
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About this data
RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase Smart Search, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.
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