Company lists · Data refreshed September 2026

Top 15 Clinical decision support systems based in the United States

RevenueBase identified 35 clinical decision support systems headquartered in the United States as of September 2026 and tracks 1,138 professional contacts across them, including 440 with verified work emails. Seattle is the largest hub.

This list covers clinical decision support systems headquartered in the United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, its RevenueBase Smart Search rating, and when it was last checked. Data refreshed September 16, 2026.

Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase Smart Search, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.

How to read this list HQ checked on every row RevenueBase Smart Search rating on every row Refreshed Sep 16, 2026 86% judged on-target in blind review
35Companies
1,138Contacts tracked
440Verified emails
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The 15 largest clinical decision support systems based in the United States

Ranked by team size
Top 15 of 35 clinical decision support systems based in the United States, ranked by team size, largest first. Data refreshed Sep 16, 2026. RevenueBase Smart Search rates how each company's information relates to clinical decision support systems: strong evidence (its own description names it), partial (names part of it), indirect (matched on the rest of its profile rather than the description shown). Click a contact count to view that company's people.
#CompanyRevenueBase Smart SearchHeadquartersEmployeesContacts
1Strong evidenceSeattle, WA, United StatesHQ checked Sep 16, 2026201-500516 contacts →

Strong evidence

“MCG Health, part of the Hearst Health network, develops evidence-based guidelines and artificial intelligence solutions that are the source of truth for clinical decision-making.”

Source: RevenueBase Database · checked Sep 16, 2026
2Strong evidenceWaltham, MA, United StatesHQ checked Sep 16, 20265,001-10,000242 contacts →

Strong evidence

“UpToDate® is a leading clinical decision support solution, trusted by clinicians and healthcare enterprises worldwide to help make confident, evidence-based decisions.”

Source: RevenueBase Database · checked Sep 16, 2026
3Strong evidenceNashville, TN, United StatesHQ checked Sep 16, 202611-5061 contacts →

Strong evidence

“EvidenceCare is a physician-centered clinical decision support platform that empowers better care decisions throughout the patient’s hospital care journey with the vision that…”

Source: RevenueBase Database · checked Sep 16, 2026
4Indirect evidenceNew York, NY, United StatesHQ checked Sep 16, 202611-5046 contacts →

Indirect evidence

“MDCalc is entering its 20th year.”

Source: RevenueBase Database · checked Sep 16, 2026
5Partial evidenceMiami, FL, United StatesHQ checked Sep 16, 202611-5023 contacts →

Partial evidence

“Real-time clinical reasoning built around your practice.”

Source: RevenueBase Database · checked Sep 16, 2026
6Indirect evidenceEl Cerrito, CA, United StatesHQ checked Sep 16, 202611-5021 contacts →

Indirect evidence

“WE ARE DOCTORS.”

Source: RevenueBase Database · checked Sep 16, 2026
7Strong evidenceSperryville, VA, United StatesHQ checked Sep 16, 202611-5015 contacts →

Strong evidence

“We support healthcare providers and improve patient outcomes by providing concise, reliable, and accessible clinical guidance and technologies that support treatment…”

Source: RevenueBase Database · checked Sep 16, 2026
8Indirect evidenceSeattle, WA, United StatesHQ checked Sep 16, 202611-5014 contacts →

Indirect evidence

“Tactuum is a digital consulting firm, specializing in digital tools and services that enrich the wellbeing of people.”

Source: RevenueBase Database · checked Sep 16, 2026
9Strong evidenceAnn Arbor, MI, United StatesHQ checked Sep 16, 202611-5010 contacts →

Strong evidence

“Isabel Healthcare provides a clinical reasoning support tool to help physicians broaden their differential and manage clinical uncertainty.”

Source: RevenueBase Database · checked Sep 16, 2026
10Strong evidenceCoeur D Alene, ID, United StatesHQ checked Sep 16, 20261-1010 contacts →

Strong evidence

“XYGene is on a mission to become the number one platform for diagnostic and treatment decision support.”

Source: RevenueBase Database · checked Sep 16, 2026
11Indirect evidenceSeattle, WA, United StatesHQ checked Sep 16, 202611-505 contacts →

Indirect evidence

“YouScript is on a mission to eliminate avoidable adverse drug events.”

Source: RevenueBase Database · checked Sep 16, 2026
12Strong evidenceBoston, MA, United StatesHQ checked Sep 16, 20261-105 contacts →

Strong evidence

“Guided Clinical Solutions is building the next generation of clinical decision support technology to revolutionize patient safety by preventing errors.”

Source: RevenueBase Database · checked Sep 16, 2026
13Strong evidenceDayton, OH, United StatesHQ checked Sep 16, 20261-104 contacts →

Strong evidence

“MedsEngine is an EHR-integrated clinical decision support application that generates real-time, personalized, evidence-based medical therapy recommendations for chronic diseases…”

Source: RevenueBase Database · checked Sep 16, 2026
14Indirect evidenceSaint Johns, FL, United StatesHQ checked Sep 16, 202611-502 contacts →

Indirect evidence

“Innovating healthcare technology through a CDSS which increases value added time, decreasing variability in care, and leverages providers to employ evidence-based medicine.”

Source: RevenueBase Database · checked Sep 16, 2026
15Strong evidenceTysons, VA, United StatesHQ checked Sep 16, 20261-101 contacts →

Strong evidence

“Healthy AI is a clinical decision support platform built to bring precision, speed, and transparency to diagnostic and triage workflows.”

Source: RevenueBase Database · checked Sep 16, 2026

Showing 15 of 35 clinical decision support systems based in the United States

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Clinical decision support systems based in the United States at a glance

As of Sep 16, 2026
38.7%Verified-email coverage
32.5Average contacts per company
11-50Median size (employees)
8.6%Largest-city concentration · Seattle
Sep 16, 2026Page data refreshed

Companies by employee count

1-10
16
11-50
13
51-200
4
201-500
1
5,001-10,000
1

Email recency for this list is measured worldwide rather than for United States, so it is reported there. Company counts and contact totals on this page are exact for United States, over 35 companies.

How this list was built

Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among clinical decision support systems, so some rows will be adjacent to the category rather than pure plays. The description and RevenueBase Smart Search rating on every row are there so you can check each match yourself.

Source
The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase Smart Search, the natural-language company search available to every RevenueBase user.
What qualifies
Companies headquartered in the United States whose own description of what they do matches “clinical decision support systems”. Matching reads each company's description, not its industry code or its name.
RevenueBase Smart Search
RevenueBase Smart Search is how this list is assembled and how each row is rated. RevenueBase's data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to a category defined in a user's own words. Each row is rated strong evidence (its own description names clinical decision support systems), partial evidence (it names part of the category) or indirect evidence (the description shown names none of it and the match rests on the rest of the company's profile). The description supporting each rating is quoted on the row.
What we exclude
Companies whose own description does not clearly place them among clinical decision support systems, and records with no verified work email. Companies headquartered outside United States are excluded even when they keep an office there.
Match quality
In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and its RevenueBase Smart Search rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
Ranking
Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
Verification
Every listed company carries at least one verified work email, 440 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
Refresh
This page's figures were pulled from the company graph on September 16, 2026. Lists refresh periodically as the graph is re-checked.
Corrections
Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.

Frequently asked

What is RevenueBase Smart Search?

RevenueBase Smart Search is how RevenueBase decides which companies belong on this list and how strongly each one fits. Its data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to the category the list is about. Each row is rated strong evidence when the company's own description names clinical decision support systems, partial evidence when it names part of the category, and indirect evidence when the description shown names none of it and the match rests on the rest of the company's profile.

How many clinical decision support systems are there based in the United States?

RevenueBase identified 35 clinical decision support systems headquartered in the United States as of September 2026, matched on each company's own description of what it does rather than its industry code.

What is the largest company on this list?

MCG Health, headquartered in Seattle, tops this list with the largest team on record.

Which city has the most clinical decision support systems?

Seattle leads with 3 headquartered companies, followed by Boston (2) and New York (2).

How do I get contact information for these companies?

A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 440 verified decision-maker contacts tracked across these 35 companies.

How current is this list?

The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 16, 2026.

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About this data

RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase Smart Search, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.