Company lists · Data refreshed September 2026
Top 25 Clinical decision support software companies based in the United States
RevenueBase identified 122 clinical decision support software companies headquartered in the United States as of September 2026 and tracks 3,243 professional contacts across them, including 1,145 with verified work emails. Boston is the largest hub.
This list covers clinical decision support software companies headquartered in the United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, its RevenueBase Smart Search rating, and when it was last checked. Data refreshed September 14, 2026.
Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase Smart Search, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.
The 25 largest clinical decision support software companies based in the United States
Ranked by team size| # | Company | Contacts | |||
|---|---|---|---|---|---|
| 1 | 516 contacts → | ||||
Strong evidence “MCG Health, part of the Hearst Health network, develops evidence-based guidelines and artificial intelligence solutions that are the source of truth for clinical decision-making.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 2 | 242 contacts → | ||||
Strong evidence “UpToDate® is a leading clinical decision support solution, trusted by clinicians and healthcare enterprises worldwide to help make confident, evidence-based decisions.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 3 | 145 contacts → | ||||
Partial evidence “Digital Infuzion is a software and health care IT company.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 4 | 115 contacts → | ||||
Partial evidence “Clinical Architecture is the leading provider of innovative healthcare IT solutions focused on the quality and usability of clinical information.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 5 | 103 contacts → | ||||
Indirect evidence “Regard, a New York City based healthcare company, creates technology that enriches and advances the practice of medicine.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 6 | 96 contacts → | ||||
Strong evidence “At VisualDx, we’re a team of physicians, educators, and technologists headquartered in Rochester, NY with a mission to make clinical decision-making faster, easier, and more…” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 7 | 91 contacts → | ||||
Partial evidence “Cognitive, an information technology and software engineering professional services company, is dedicated to one thing: elevating the quality, speed and delivery of today’s US…” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 8 | 82 contacts → | ||||
Indirect evidence “EndoSoft® is a leading healthcare information technology company.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 9 | 79 contacts → | ||||
Strong evidence “Building the next generation of intelligent clinical software!” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 10 | 61 contacts → | ||||
Strong evidence “EvidenceCare is a physician-centered clinical decision support platform that empowers better care decisions throughout the patient’s hospital care journey with the vision that…” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 11 | 60 contacts → | ||||
Strong evidence “Amalgam Rx empowers patients and providers to make the best decisions possible-within clinical workflows and everyday life.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 12 | 53 contacts → | ||||
Partial evidence “Vital Decisions is now Evolent.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 13 | 52 contacts → | ||||
Indirect evidence “Using our native AI platform that is specifically optimized for oncology, Inspirata AI helps cancer programs identify reportable cancer cases in real time, directly from source…” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 14 | 50 contacts → | ||||
Indirect evidence “When your system goes down, we lift you up.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 15 | 46 contacts → | ||||
Indirect evidence “MDCalc is entering its 20th year.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 16 | 45 contacts → | ||||
Indirect evidence “Evolko is simple, easy to use and designed for specialists.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 17 | 44 contacts → | ||||
Strong evidence “VivproAI offers a revolutionary biointelligence software platform and innovative services to make evidence-based clinical, regulatory, and business decisions at lightning speed…” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 18 | 43 contacts → | ||||
Partial evidence “Quantros is a leading provider of software-based solutions and services to healthcare.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 19 | 42 contacts → | ||||
Partial evidence “Since 1994, PEPID has been a leading developer of clinical and drug information resources and mobile apps for healthcare providers, hospitals and schools.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 20 | 29 contacts → | ||||
Partial evidence “Since Cedaron's founding with a NASA grant in 1990, the company's objective has been to create cutting edge medical software solutions and to deliver these technologies with best…” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 21 | 23 contacts → | ||||
Strong evidence “We take the incredibly complex clinical world of medicine and create a brilliantly simple software so that healthcare professionals can provide high quality and efficient care.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 22 | 23 contacts → | ||||
Partial evidence “Softbir is a medical software focused company based in Indianapolis, Indiana that is improving healthcare through technology-enabled solutions.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 23 | 23 contacts → | ||||
Partial evidence “Real-time clinical reasoning built around your practice.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 24 | 21 contacts → | ||||
Indirect evidence “WE ARE DOCTORS.” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
| 25 | 20 contacts → | ||||
Partial evidence “Care Everywhere provides software solutions to the healthcare industry” Source: RevenueBase Database · checked Sep 14, 2026Thanks. The Data Team will review it. | |||||
RevenueBase Smart Search
RevenueBase Smart Search assesses information from a company’s LinkedIn profile, information supplied directly by the company, its website, and other publicly available sources. It uses that information to rate how closely the company relates to this list’s category: clinical decision support software companies. Every row carries its rating and the description the rating was read from, so each one can be checked rather than taken on trust.
- Strong evidence
- The company's own public description of its business names clinical decision support software companies.
- Partial evidence
- Its own public description names part of clinical decision support software companies, so it works in or next to the category without describing itself that way.
- Indirect evidence
- The description shown does not name clinical decision support software companies. The match rests on the rest of the company's public profile rather than the one sentence quoted here, so this is the rating to check first.
RevenueBase Smart Search is how these lists are built: RevenueBase's data engine and AI assemble the companies that match a category defined in a user's own words, so a list can be about what companies actually do rather than about whichever industry code they were filed under.
Showing 25 of 122 clinical decision support software companies based in the United States
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Clinical decision support software companies based in the United States at a glance
As of Sep 14, 2026Companies by employee count
Email recency for this list is measured worldwide rather than for United States, so it is reported there. Company counts and contact totals on this page are exact for United States, over 122 companies.
How this list was built
Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among clinical decision support software companies, so some rows will be adjacent to the category rather than pure plays. The description and RevenueBase Smart Search rating on every row are there so you can check each match yourself.
- Source
- The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase Smart Search, the natural-language company search available to every RevenueBase user.
- What qualifies
- Companies headquartered in the United States whose own description of what they do matches “clinical decision support software companies”. Matching reads each company's description, not its industry code or its name.
- RevenueBase Smart Search
- RevenueBase Smart Search is how this list is assembled and how each row is rated. RevenueBase's data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to a category defined in a user's own words. Each row is rated strong evidence (its own description names clinical decision support software companies), partial evidence (it names part of the category) or indirect evidence (the description shown names none of it and the match rests on the rest of the company's profile). The description supporting each rating is quoted on the row.
- What we exclude
- Companies whose own description does not clearly place them among clinical decision support software companies, and records with no verified work email. Companies headquartered outside United States are excluded even when they keep an office there.
- Match quality
- In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and its RevenueBase Smart Search rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
- Ranking
- Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
- Verification
- Every listed company carries at least one verified work email, 1,145 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
- Refresh
- This page's figures were pulled from the company graph on September 14, 2026. Lists refresh periodically as the graph is re-checked.
- Corrections
- Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.
Frequently asked
What is RevenueBase Smart Search?
RevenueBase Smart Search is how RevenueBase decides which companies belong on this list and how strongly each one fits. Its data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to the category the list is about. Each row is rated strong evidence when the company's own description names clinical decision support software companies, partial evidence when it names part of the category, and indirect evidence when the description shown names none of it and the match rests on the rest of the company's profile.
How many clinical decision support software companies are there based in the United States?
RevenueBase identified 122 clinical decision support software companies headquartered in the United States as of September 2026, matched on each company's own description of what it does rather than its industry code.
What is the largest company on this list?
MCG Health, headquartered in Seattle, tops this list with the largest team on record.
Which city has the most clinical decision support software companies?
Boston leads with 7 headquartered companies, followed by San Francisco (6) and New York (4).
How do I get contact information for these companies?
A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 1,145 verified decision-maker contacts tracked across these 122 companies.
How current is this list?
The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 14, 2026.
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About this data
RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase Smart Search, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.
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