Company lists · Data refreshed September 2026
Top 25 Chemical safety software companies based in the United States
RevenueBase identified 171 chemical safety software companies headquartered in the United States as of September 2026 and tracks 8,610 professional contacts across them, including 3,701 with verified work emails. Houston is the largest hub.
This list covers chemical safety software companies headquartered in the United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, its RevenueBase Smart Search rating, and when it was last checked. Data refreshed September 27, 2026.
Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase Smart Search, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.
The 25 largest chemical safety software companies based in the United States
Ranked by team size| # | Company | Contacts | |||
|---|---|---|---|---|---|
| 1 | 2,650 contacts → | ||||
Partial evidence “Total Safety is the world's premier provider of integrated safety and compliance services and the products necessary to support them, including gas detection, respiratory…” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 2 | 1,349 contacts → | ||||
Partial evidence “Sphera creates a safer, more sustainable and productive world.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 3 | 1,201 contacts → | ||||
Strong evidence “ESS is the leading provider of Environmental, Health & Safety (EHS) and Crisis Management sustainability software.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 4 | 602 contacts → | ||||
Strong evidence “3E is an AI-driven software and data company that delivers trusted compliance and sustainability intelligence-enabling companies to navigate complex chemical and product…” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 5 | 568 contacts → | ||||
Strong evidence “VelocityEHS is the global leader in EHS & Sustainability software, pioneering human-centered AI to make workplaces safer, faster.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 6 | 254 contacts → | ||||
Strong evidence “Octave Reliance (formerly ETQ Reliance) is the leading Quality, EHS, Food Safety and Compliance management software for identifying, mitigating and preventing high-risk events…” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 7 | 243 contacts → | ||||
Partial evidence “Justrite Safety Group (JSG) manufactures and provides industrial safety solutions.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 8 | 177 contacts → | ||||
Partial evidence “Haas TCM is a global chemical management services company.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 9 | 95 contacts → | ||||
Strong evidence “Locus Technologies is the only scientist-driven software company at the nexus of analytical and field data management, Environmental, Health, and Safety (EHS) compliance, and…” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 10 | 81 contacts → | ||||
Indirect evidence “Encamp is an enterprise technology company on a mission to create a world in which what’s good for business can be good for the environment.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 11 | 78 contacts → | ||||
Partial evidence “Through innovation and dedication to continual improvement, ioMosaic has become a leading provider of integrated process safety and risk management solutions.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 12 | 67 contacts → | ||||
Partial evidence “ChemicalSafety provides industry-leading environmental technology for chemical, facility, and hazardous waste management, as well as compliance with local, national and…” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 13 | 50 contacts → | ||||
Strong evidence “SafeBridge is the premier resource for high-level safety and health consulting to the pharmaceutical, biotechnology, and specialty chemicals industries.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 14 | 48 contacts → | ||||
Partial evidence “Risk & Safety Solutions was founded to support the University of California, one of the world's leading research institutions.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 15 | 45 contacts → | ||||
Partial evidence “ChemDAQ’s mission is to empower customers to eliminate workplace exposure to toxic chemicals through innovative monitoring and control solutions, industry-leading partnerships…” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 16 | 45 contacts → | ||||
Strong evidence “Frontline Data Solutions (fldata.com) develops and supports web-based EHS software products that enhance safety, productivity and compliance for heavily-regulated and high-risk…” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 17 | 44 contacts → | ||||
Indirect evidence “APSM started in the early 1990s as a consulting firm assisting companies with the OSHA, PSM, and EPA RMP regulations.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 18 | 43 contacts → | ||||
Indirect evidence “Provenance Consulting is now a part of Trinity Consultants.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 19 | 41 contacts → | ||||
Partial evidence “Scilligence is a leading innovator of cross-platform, mobile cheminformatics and bioinformatics software solutions.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 20 | 32 contacts → | ||||
Indirect evidence “Clean Ideas from Ecolink: Work smarter, work cleaner, save money.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 21 | 30 contacts → | ||||
Strong evidence “StarTex Software provides software solutions including EHS Insight, the easy-to-use, cost effective solution for Environmental, Health & Safety (EHS) Management and Corporate…” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 22 | 24 contacts → | ||||
Indirect evidence “A COMMON-SENSE APPROACH Dealing with hazardous substances in your workplace can make your life a lot more complicated.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 23 | 23 contacts → | ||||
Strong evidence “TotalSDS is dedicated to making the workplace and the environment safer by simplifying compliance and chemical information documentation.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 24 | 21 contacts → | ||||
Partial evidence “Affygility Solutions provides environmental, health and safety services to the life sciences industry.” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
| 25 | 20 contacts → | ||||
Strong evidence “Maerix is the undisputed leader in the development of management software used mainly by specialists in health, safety, environment (OHS/EHS), production and human resources (HR).” Source: RevenueBase Database · checked Sep 27, 2026Thanks. The Data Team will review it. | |||||
RevenueBase Smart Search
RevenueBase Smart Search assesses information from a company’s LinkedIn profile, information supplied directly by the company, its website, and other publicly available sources. It uses that information to rate how closely the company relates to this list’s category: chemical safety software companies. Every row carries its rating and the description the rating was read from, so each one can be checked rather than taken on trust.
- Strong evidence
- The company's own public description of its business names chemical safety software companies.
- Partial evidence
- Its own public description names part of chemical safety software companies, so it works in or next to the category without describing itself that way.
- Indirect evidence
- The description shown does not name chemical safety software companies. The match rests on the rest of the company's public profile rather than the one sentence quoted here, so this is the rating to check first.
RevenueBase Smart Search is how these lists are built: RevenueBase's data engine and AI assemble the companies that match a category defined in a user's own words, so a list can be about what companies actually do rather than about whichever industry code they were filed under.
Showing 25 of 171 chemical safety software companies based in the United States
See the full list, filter by size, metro and specialty, and get verified emails and direct dials for all 3,701 reachable decision-makers.
Free signup · no credit card
Chemical safety software companies based in the United States at a glance
As of Sep 27, 2026Companies by employee count
Email recency for this list is measured worldwide rather than for United States, so it is reported there. Company counts and contact totals on this page are exact for United States, over 171 companies.
How this list was built
Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among chemical safety software companies, so some rows will be adjacent to the category rather than pure plays. The description and RevenueBase Smart Search rating on every row are there so you can check each match yourself.
- Source
- The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase Smart Search, the natural-language company search available to every RevenueBase user.
- What qualifies
- Companies headquartered in the United States whose own description of what they do matches “chemical safety software companies”. Matching reads each company's description, not its industry code or its name.
- RevenueBase Smart Search
- RevenueBase Smart Search is how this list is assembled and how each row is rated. RevenueBase's data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to a category defined in a user's own words. Each row is rated strong evidence (its own description names chemical safety software companies), partial evidence (it names part of the category) or indirect evidence (the description shown names none of it and the match rests on the rest of the company's profile). The description supporting each rating is quoted on the row.
- What we exclude
- Companies whose own description does not clearly place them among chemical safety software companies, and records with no verified work email. Companies headquartered outside United States are excluded even when they keep an office there.
- Match quality
- In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and its RevenueBase Smart Search rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
- Ranking
- Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
- Verification
- Every listed company carries at least one verified work email, 3,701 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
- Refresh
- This page's figures were pulled from the company graph on September 27, 2026. Lists refresh periodically as the graph is re-checked.
- Corrections
- Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.
Frequently asked
What is RevenueBase Smart Search?
RevenueBase Smart Search is how RevenueBase decides which companies belong on this list and how strongly each one fits. Its data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to the category the list is about. Each row is rated strong evidence when the company's own description names chemical safety software companies, partial evidence when it names part of the category, and indirect evidence when the description shown names none of it and the match rests on the rest of the company's profile.
How many chemical safety software companies are there based in the United States?
RevenueBase identified 171 chemical safety software companies headquartered in the United States as of September 2026, matched on each company's own description of what it does rather than its industry code.
What is the largest company on this list?
Total Safety, headquartered in Pasadena, tops this list with the largest team on record.
Which city has the most chemical safety software companies?
Houston leads with 9 headquartered companies, followed by Wilmington (4) and Arlington (3).
How do I get contact information for these companies?
A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 3,701 verified decision-maker contacts tracked across these 171 companies.
How current is this list?
The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 27, 2026.
Ready to reach these companies? Verified emails and direct dials for all 171 chemical safety software companies based in the United States. Start with a free account, no credit card.
Download this list →Related lists
Chemical safety software companies by geography
- Chemical safety software companies based in Brazil
- Chemical safety software companies based in Canada
- Chemical safety software companies based in France
- Chemical safety software companies based in Germany
- Chemical safety software companies based in Italy
- Chemical safety software companies based in the Netherlands
- Chemical safety software companies based in the United Kingdom
About this data
RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase Smart Search, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.
More company lists
- All company lists
- Lists by location
- Lists A-Z
- New lists
- Chemical safety software companies based in Brazil
- Chemical safety software companies based in Canada
- Chemical safety software companies based in France
- Chemical safety software companies based in Germany
- Chemical safety software companies based in Italy
- Chemical safety software companies based in the Netherlands