Company lists · Data refreshed November 2026

Top 25 Enzyme replacement therapy manufacturers worldwide

RevenueBase identified 118 company matches for enzyme replacement therapy manufacturers worldwide as of November 2026 and tracks 10,746 professional contacts across them, including 3,766 with verified work emails. The United States is the largest market and Boston the largest hub.

This list covers company matches for enzyme replacement therapy manufacturers worldwide, found by RevenueBase SmartSearch using the meaning of business descriptions in its company graph at Exact. Ranked by professionals tracked, largest first. Rows show recorded descriptions where available, Exact search membership and the snapshot date. Data refreshed November 6, 2026. Country and city lists for enzyme replacement therapy manufacturers follow the table.

Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase SmartSearch, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.

How to read this list RevenueBase SmartSearch · Exact Recorded Nov 6, 2026 How this list was built
118Companies
10,746Contacts tracked
3,766Verified emails
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The 25 largest enzyme replacement therapy manufacturers worldwide

Ranked by team size
Top 25 of 118 company matches for enzyme replacement therapy manufacturers worldwide, ordered by professional contacts tracked in RevenueBase, largest first. Recorded Nov 6, 2026. The RevenueBase SmartSearch column shows Exact match membership in this saved search. Click a contact count to view that company's people. Totals use company locations recorded by RevenueBase; the displayed preview is a smaller selection.
#CompanyRevenueBase SmartSearchHeadquartersEmployeesContacts
1Exact matchNovato, United StatesHQ recorded Nov 6, 20261,001-5,0001,639 contacts →

Exact match

“Leading with purpose.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
2Exact matchPalo Alto, CA, United StatesHQ recorded Nov 6, 2026501-1,0001,021 contacts →

Exact match

“We exist to bring transformative medicines to people living with genetic conditions.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
3Exact matchPrinceton, NJ, United StatesHQ recorded Nov 6, 2026501-1,000582 contacts →

Exact match

“Amicus Therapeutics is now part of BioMarin Pharmaceutical Inc, a leading, global rare disease biotechnology company focused on delivering medicines for people living with…”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
4Exact matchFoster City, CA, United StatesHQ recorded Nov 6, 2026201-500431 contacts →

Exact match

“Mirum Pharmaceuticals is a leading rare disease company with a global footprint of approved products and a broad pipeline of investigational medicines.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
5Exact matchWaltham, MA, United StatesHQ recorded Nov 6, 2026201-500336 contacts →

Exact match

“Sobi is an international specialty healthcare company dedicated to developing treatments and extensive patient support networks for people with rare and difficult to treat…”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
6Exact matchBeccar, ArgentinaHQ recorded Nov 6, 2026201-500234 contacts →

Exact match

“Focused on complex therapies and orphan diseases, Varifarma is a company which is devoted to improving the patients' quality of life.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
7Exact matchNagoya, JapanHQ recorded Nov 6, 2026501-1,000107 contacts →

Exact match

“We’re Amano Enzyme (or Amano for short), and our dedication to advancing enzyme technology has been unwavering for generations.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
8Exact matchWaltham, MA, United StatesHQ recorded Nov 6, 202651-200101 contacts →

Exact match

“Alcresta Therapeutics is dedicated to developing and commercializing novel, enzyme-based products designed to address challenges faced by people living with gastrointestinal…”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
9Exact matchCardiff, United KingdomHQ recorded Nov 6, 202651-20090 contacts →

Exact match

“Biocatalysts is a biotechnology company producing speciality enzymes at commercial scales for a variety of industries.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
10Exact matchBoston, MA, United StatesHQ recorded Nov 6, 202651-20089 contacts →

Exact match

“We are a fully integrated, commercial-stage biopharmaceutical company driving progress for people living with rare immune disorders.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
11Exact matchPhiladelphia, PA, United StatesHQ recorded Nov 6, 202651-20070 contacts →

Exact match

“GEMMABio, a new therapeutics company, will serve as the research and innovation arm to speed the research of and global access to life-changing advanced therapies for those living…”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
12Exact matchLeipzig, GermanyHQ recorded Nov 6, 202651-20069 contacts →

Exact match

“c-LEcta is a global biotechnology company with over 20 years experience in the development, production and distribution of enzyme products.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
13Exact matchLake Forest, IL, United StatesHQ recorded Nov 6, 202651-20052 contacts →

Exact match

“Jaguar Gene Therapy, LLC is dedicated to accelerating breakthroughs in gene therapy for patients suffering from severe genetic diseases including those that impact sizeable…”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
14Exact matchTromsø, NorwayHQ recorded Nov 6, 202651-20051 contacts →

Exact match

“ArcticZymes Technologies ASA (OSE: AZT): Enzymes Engineered for Breakthroughs, We deliver high-performance enzymes that power molecular diagnostics, gene therapy, and vaccine…”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
15Exact matchMadrid, SpainHQ recorded Nov 6, 2026201-50041 contacts →

Exact match

“Founded in 2010, Proteos Biotech is a biotech company specialising in the manufacture of recombinant enzymes and CMO services that involve manufacturing pharmaceutical products…”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
16Exact matchNatick, MA, United StatesHQ recorded Nov 6, 202611-5035 contacts →

Exact match

“Anagram is a clinical stage company leveraging proprietary enzyme technologies and expertise in gastrointestinal diseases to solve complex problems and advance a pipeline of…”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
17Exact matchCary, NC, United StatesHQ recorded Nov 6, 202611-5032 contacts →

Exact match

“Most people are told their labs are normal while they're still exhausted, foggy, and feeling like a stranger in their own body.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
18Exact matchBoston, MA, United StatesHQ recorded Nov 6, 202611-5031 contacts →

Exact match

“We are a biopharmaceutical company specializing in the development of novel therapeutics to treat rare metabolic diseases.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
19Exact matchNaarden, NetherlandsHQ recorded Nov 6, 202611-5028 contacts →

Exact match

“We are developing new treatment options to help patients with rare metabolic disorders.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
20Exact matchSolana Beach, CA, United StatesHQ recorded Nov 6, 202611-5027 contacts →

Exact match

“Sentynl Therapeutics, a wholly owned subsidiary of Zydus Lifesciences Ltd, is a commercial stage biopharmaceutical company focused on bringing innovative therapies to patients…”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
21Exact matchDubai, United Arab EmiratesHQ recorded Nov 6, 202611-5025 contacts →

Exact match

“EPYGEN is an Biotechnology organization, headquartered in Dubiotech Park, Dubai, UAE, with offices, labs and manufacturing facilities in Dubai, India and USA.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
22Exact matchSan Carlos, CA, United StatesHQ recorded Nov 6, 20261-1024 contacts →

Exact match

“Glycomine is developing orphan drugs for serious rare disorders of metabolism and protein misfolding for which no other therapeutic options exist.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
23Exact matchNew Haven, CT, United StatesHQ recorded Nov 6, 202611-5021 contacts →

Exact match

“Rallybio (NASDAQ: RLYB) is a clinical-stage biotechnology company with a mission to develop and commercialize life-transforming therapies for patients with severe and rare…”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
24Exact matchSt. Louis, MO, United StatesHQ recorded Nov 6, 20261-1019 contacts →

Exact match

“M6P Therapeutics is developing the next-generation enzyme replacement and gene therapies for lysosomal storage disorders.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase
25Exact matchUtrecht, NetherlandsHQ recorded Nov 6, 202611-5018 contacts →

Exact match

“AM-Pharma’s purpose is to save and improve the lives of patients confronted with severe medical conditions.”

Recorded in the RevenueBase company graph · Nov 6, 2026 · View company records in RevenueBase

Showing 25 of 118 enzyme replacement therapy manufacturers worldwide

See the full list, filter by size, metro and specialty, and access 3,766 tracked professional contacts with verified work emails. Direct dials are available where recorded.

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Enzyme replacement therapy manufacturers worldwide at a glance

As of Nov 6, 2026
35.0%Verified-email coverage
91.1Average contacts per company
11-50Median size (employees)
2.5%Largest-city concentration · Boston
Nov 6, 2026Page data refreshed

Companies by employee count

1-10
40
11-50
38
51-200
21
201-500
8
501-1,000
5
1,001-5,000
4
10001+
1

Email recency is reported on each country list linked below.

How this list was built

The recorded descriptions help you assess these company matches. Check a company’s website for its current services and locations.

Source
The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase SmartSearch, the natural-language company search available to every RevenueBase user.
Coverage
Every country. Country and city lists for enzyme replacement therapy manufacturers are linked below.
What qualifies
Company records worldwide whose business descriptions match “enzyme replacement therapy manufacturers” by meaning at the Exact setting. Descriptions are compiled in the RevenueBase company graph from public websites, profiles and company information where available; they are not guaranteed quotations from the company's website.
RevenueBase SmartSearch
Describe a niche company in your own words to find businesses by meaning. Exact, Similar, Related and Broad control the breadth of RevenueBase SmartSearch. This saved list uses Exact. Each row's Exact match badge shows inclusion in that search, not an individual score or a service-quality judgment.
Public preview
The public preview omits records without a verified work email. Dataset totals and geographic summaries describe the full matched records before these preview filters.
Match quality
RevenueBase's August 25, 2026 study assessed 4,198 description/company pairs across matching settings. The publisher reports 86% good or better at Exact. This evaluates the method across queries; it does not audit this individual list. Recorded company descriptions, where available, help you judge each match yourself. Read the full methodology: how the lists are built and what the study measures.
Ranking
Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
Verification
Every displayed company carries at least one verified work email. RevenueBase tracks 3,766 professional contacts with verified work emails across the full matched dataset. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
Refresh
This page's figures were pulled from the company graph on November 6, 2026. Lists refresh periodically as the graph is re-checked.
Record context
Company records and descriptions can change. Check the company's website for its current services and locations.

Enzyme replacement therapy manufacturers by location

1 lists · largest first

Every Enzyme replacement therapy manufacturers list RevenueBase publishes, by country and city. Counts are matching companies in each list as of its own refresh date.

Countries

Frequently asked

What is RevenueBase SmartSearch?

RevenueBase SmartSearch finds niche companies by the meaning of their business descriptions in the RevenueBase company graph. Exact, Similar, Related and Broad control how closely companies must fit your description. This list uses Exact for “enzyme replacement therapy manufacturers”; each Exact match badge shows search membership, not an individual similarity or quality score.

How many enzyme replacement therapy manufacturers are there worldwide?

RevenueBase identified 118 company matches for enzyme replacement therapy manufacturers worldwide as of November 2026, using the meaning of business descriptions at Exact. This is the recorded matched set in the RevenueBase company graph.

What is the largest company on this list?

Ultragenyx tops the displayed preview by professional contacts tracked in RevenueBase. Recorded headquarters appear in the company rows.

Which country has the most enzyme replacement therapy manufacturers?

The United States leads with 49 companies. Every enzyme replacement therapy manufacturers list by country and city is linked on this page.

Which city has the most enzyme replacement therapy manufacturers?

Boston leads with 3 company records, followed by Boca Raton (2) and Waltham (2).

How do I get contact information for these companies?

A free RevenueBase account lets you run this exact search and work limited free results with 500 credits to start. Upgrading provides access to the 3,766 professional contacts with verified work emails tracked across these 118 companies; direct dials are available where recorded.

How current is this list?

The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on November 6, 2026.

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About this data

RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase SmartSearch, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.