Company lists · Data refreshed September 2026

Top 25 Blockchain companies based in San Francisco, United States

RevenueBase identified 132 blockchain companies headquartered in San Francisco, United States as of September 2026 and tracks 3,459 professional contacts across them, including 791 with verified work emails. New York is the largest hub.

This list covers blockchain companies headquartered in San Francisco, United States, matched on what each company actually does as described in its own words. Ranked by team size, largest first. Every row shows the company's own description, its RevenueBase Smart Search rating, and when it was last checked. Data refreshed September 7, 2026.

Published by RevenueBase, a B2B data infrastructure company. This list was built with RevenueBase Smart Search, the natural-language company search RevenueBase customers use to build their own targeted lists and unlock verified emails and direct dials at the companies on them. How these lists are built and judged.

How to read this list HQ checked on every row RevenueBase Smart Search rating on every row Refreshed Sep 7, 2026 86% judged on-target in blind review
132Companies
3,459Contacts tracked
791Verified emails
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The 25 largest blockchain companies based in San Francisco, United States

Ranked by team size
Top 25 of 132 blockchain companies based in San Francisco, United States, ranked by team size, largest first. Data refreshed Sep 7, 2026. RevenueBase Smart Search rates how each company's information relates to blockchain companies: strong evidence (its own description names it), partial (names part of it), indirect (matched on the rest of its profile rather than the description shown). Click a contact count to view that company's people.
#CompanyRevenueBase Smart SearchHeadquartersEmployeesContacts
1Strong evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 2026501-1,0001,275 contacts →

“Using proven crypto and blockchain technology honed over a decade, Ripple’s enterprise-grade solutions are faster, more transparent, and more cost-effective than traditional…”

Source: company website · checked Sep 7, 2026
2Indirect evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 2026201-500345 contacts →

“TRM Labs is an AI investigations company that helps keep people, institutions, and communities safe from crime.”

Source: company website · checked Sep 7, 2026
3Strong evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202651-200329 contacts →

“Alchemy powers the blockchain infrastructure to accelerate the world's leading financial applications.”

Source: company website · checked Sep 7, 2026
4Strong evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202611-50117 contacts →

“Traditional blockchains were designed for human users.”

Source: company website · checked Sep 7, 2026
5Strong evidenceSan Francisco, United StatesHQ checked Sep 7, 202611-50108 contacts →

“Polychain invests in protocols and companies in the blockchain space, advancing the global adoption of cryptocurrencies.”

Source: company website · checked Sep 7, 2026
6Strong evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202611-5094 contacts →

Blockchain Capital was founded in 2013 with the mission of helping entrepreneurs build world-class companies and projects based on blockchain technology – providing founders with…”

Source: company website · checked Sep 7, 2026
7Indirect evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202611-5070 contacts →

“ZetaChain is the private memory layer for AI and the infrastructure behind the AI consumer layer.”

Source: company website · checked Sep 7, 2026
8Strong evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202651-20067 contacts →

“Quantstamp is a global leader in blockchain security, on a mission to secure the future of web3.”

Source: company website · checked Sep 7, 2026
9Indirect evidenceSan Francisco, United StatesHQ checked Sep 7, 202611-5067 contacts →

“We are now known as The DATA Foundation.”

Source: company website · checked Sep 7, 2026
10Strong evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202611-5053 contacts →

“Created by Bram Cohen, the inventor of BitTorrent, the underlying open source, public Chia blockchain provides the secure and regulatory-compliant infrastructure for One Market.”

Source: company website · checked Sep 7, 2026
11Indirect evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202611-5040 contacts →

“Onboard users with wallets, build & deploy smart contracts, accept fiat with payments, and scale apps with infrastructure, on any EVM chain.”

Source: company website · checked Sep 7, 2026
12Indirect evidenceSan Francisco, United StatesHQ checked Sep 7, 202611-5036 contacts →

“Framework Ventures is a leading VC firm with a track record of partnering with winning founders.”

Source: company website · checked Sep 7, 2026
13Indirect evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202651-20036 contacts →

“Welcome to N3TWORK Studios!”

Source: company website · checked Sep 7, 2026
14Strong evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202611-5035 contacts →

“Loyyal is at the forefront of loyalty and payments innovation, offering a cutting-edge Enterprise SaaS Suite powered by patented blockchain technology.”

Source: company website · checked Sep 7, 2026
15Strong evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202611-5034 contacts →

“Constellation is the world’s only Blockchain technology designed for Big Data, providing infrastructure for an open decentralized data marketplace and an enterprise-grade software…”

Source: company website · checked Sep 7, 2026
16Strong evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202611-5030 contacts →

“Agoric is a blockchain product company building seamless, intelligent cross-chain applications-powered by Orchestration.”

Source: company website · checked Sep 7, 2026
17Indirect evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202611-5023 contacts →

“Eclipse is a verifiable computing company based in San Francisco, founded in 2022.”

Source: company website · checked Sep 7, 2026
18Indirect evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202611-5020 contacts →

“At LBank Labs, we thrive on the power of connections and believe in fostering strong relationships within the industry.”

Source: company website · checked Sep 7, 2026
19Strong evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202611-5018 contacts →

“Ambisafe is a globally recognized blockchain-based software provider.”

Source: company website · checked Sep 7, 2026
20Strong evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202611-5015 contacts →

“We're building InfiniSVM, a high-performance, hardware-accelerated SVM blockchain engineered for unparalleled scalability and throughput.”

Source: company website · checked Sep 7, 2026
21Indirect evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202611-5013 contacts →

“At PeopleBrowsr, we are on a mission to change the way influencers, creators and brands connect with their customers/fans.”

Source: company website · checked Sep 7, 2026
22Strong evidenceSan Francisco, United StatesHQ checked Sep 7, 202611-5011 contacts →

“Momentum 6 is a venture capital, venture builder, research, and marketing firm creating the leading blockchain companies of the future.”

Source: company website · checked Sep 7, 2026
23Indirect evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 20261-1010 contacts →

“gCC is a boutique early-stage venture capital firm based in Silicon Valley.”

Source: company website · checked Sep 7, 2026
24Indirect evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 202611-509 contacts →

“Newzchain is the founder-operated startup intelligence platform for India and the India–Gulf corridor.”

Source: company website · checked Sep 7, 2026
25Indirect evidenceSan Francisco, CA, United StatesHQ checked Sep 7, 20261-109 contacts →

“Founded in 2024, Able Labs is building the next evolution of DeFi with a permissionless, decentralized protocol across multiple chains.”

Source: company website · checked Sep 7, 2026

Showing 25 of 132 blockchain companies based in San Francisco, United States

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Blockchain companies based in San Francisco, United States at a glance

As of Sep 7, 2026
22.9%Verified-email coverage
26.2Average contacts per company
11-50Median size (employees)
135.6%Largest-city concentration · New York
Sep 7, 2026Page data refreshed

Companies by employee count

1-10
62
11-50
55
51-200
10
201-500
4
501-1,000
1

Email recency for this list is measured across the whole United States list rather than this city, so it is reported there. Company counts and contact totals on this page are exact for San Francisco, over 132 companies.

How this list was built

Company categories are rarely black and white. RevenueBase reads each company's own description of its business to decide whether it belongs among blockchain companies, so some rows will be adjacent to the category rather than pure plays. The description and RevenueBase Smart Search rating on every row are there so you can check each match yourself.

Source
The RevenueBase company graph: 60 million companies and 398.9 million professional contacts resolved from primary sources, queried with RevenueBase Smart Search, the natural-language company search available to every RevenueBase user.
What qualifies
Companies headquartered in San Francisco, United States whose own description of what they do matches “blockchain companies”. Matching reads each company's description, not its industry code or its name.
RevenueBase Smart Search
RevenueBase Smart Search is how this list is assembled and how each row is rated. RevenueBase's data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to a category defined in a user's own words. Each row is rated strong evidence (its own description names blockchain companies), partial evidence (it names part of the category) or indirect evidence (the description shown names none of it and the match rests on the rest of the company's profile). The description supporting each rating is quoted on the row.
What we exclude
Companies whose own description does not clearly place them among blockchain companies, and records with no verified work email. Companies headquartered outside San Francisco are excluded even when they keep an office there.
Match quality
In blind human judging of this matching method, 86% of matched companies were on target. Expect roughly 1 in 7 rows to be adjacent to the category rather than a pure play. Every row shows the company's own description and its RevenueBase Smart Search rating so you can judge each match yourself. Read the full methodology: how the lists are built, how the judging worked, and what the figure means.
Ranking
Team size, largest first: companies are ordered by the number of professionals RevenueBase tracks at each one. Employee ranges shown are reported bands, for context.
Verification
Every listed company carries at least one verified work email, 791 across the full list. Contacts re-verify on a rolling cadence, and each contact's own verification date is shown inside RevenueBase.
Refresh
This page's figures were pulled from the company graph on September 7, 2026. Lists refresh periodically as the graph is re-checked.
Corrections
Wrong category, wrong headquarters, or a company that has closed? Use “Report an issue” on any row. Reports go to the RevenueBase Data Team and feed back into the company graph.

Frequently asked

What is RevenueBase Smart Search?

RevenueBase Smart Search is how RevenueBase decides which companies belong on this list and how strongly each one fits. Its data engine and AI assess a company's LinkedIn profile, information supplied directly by the company, its website and other publicly available information, then relate it to the category the list is about. Each row is rated strong evidence when the company's own description names blockchain companies, partial evidence when it names part of the category, and indirect evidence when the description shown names none of it and the match rests on the rest of the company's profile.

How many blockchain companies are there based in San Francisco, United States?

RevenueBase identified 132 blockchain companies headquartered in San Francisco, United States as of September 2026, matched on each company's own description of what it does rather than its industry code.

What is the largest company on this list?

Ripple, headquartered in San Francisco, tops this list with the largest team on record.

Which city has the most blockchain companies?

New York leads with 179 headquartered companies, followed by San Francisco (132) and Miami (86).

How do I get contact information for these companies?

A free RevenueBase account lets you run this exact search and work the top results, verified emails and direct dials included. Upgrading unlocks all 791 verified decision-maker contacts tracked across these 132 companies.

How current is this list?

The list refreshes periodically as the company graph is re-checked. This page's figures were pulled on September 7, 2026.

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About this data

RevenueBase is a B2B data infrastructure company. Its company graph covers 60 million companies and 398.9 million professional contacts, with emails verified on a rolling cadence rather than scraped once and left to decay. These company lists are generated directly from that graph with RevenueBase Smart Search, the same natural-language company search every RevenueBase user has: describe a market in plain words, get the companies that match, and add verified emails and direct dials for the people at them. It is the same data that powers RevenueBase's B2B data products, and a free account includes 500 credits to start. How these lists are built and judged.